Evidence map›Paper›PMID 30877424›Full record

Observational studyEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2019

The role of F18-fluorocholine positron emission tomography/magnetic resonance imaging in localizing parathyroid adenomas.

Avi Khafif, Muhamed Masalha, Roee Landsberg, Liran Domachevsky, Hanna Bernstine, David Groshar, Ofer Azoulay, Yehudit Lockman

Abstract readComparative StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Assessment and Comparison ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Superior performance of 18F-fluorocholine digital PET/CT in the detection of parathyroid adenomas.European journal of nuclear medicine and molecular imaging · 2020
    Article
  6. Parathyroid imaging withEJNMMI research · 2019
    Article
  7. Comparison of Neck Ultrasonography, Dual PhaseIndian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India
    Article
  8. Role ofIndian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Avi KhafifA. R. M. Center of Otolaryngology, Head and Neck Surgery, Department of Otolaryngology, Head and Neck Surgery, Assuta Medical Center, Faculty of Medicine, Tel Aviv. Affiliated with Ben Gurion University, 20 Habarzel St., 69710, Beersheba, Israel.
Muhamed MasalhaA. R. M. Center of Otolaryngology, Head and Neck Surgery, Department of Otolaryngology, Head and Neck Surgery, Assuta Medical Center, Faculty of Medicine, Tel Aviv. Affiliated with Ben Gurion University, 20 Habarzel St., 69710, Beersheba, Israel. masalha.muhamed@gmail.com.ORCID http://orcid.org/0000-0001-7344-4962
Roee LandsbergA. R. M. Center of Otolaryngology, Head and Neck Surgery, Department of Otolaryngology, Head and Neck Surgery, Assuta Medical Center, Faculty of Medicine, Tel Aviv. Affiliated with Ben Gurion University, 20 Habarzel St., 69710, Beersheba, Israel.
Liran DomachevskyDepartment of Nuclear Medicine, Assuta Medical Center, Faculty of Medicine, Tel Aviv. Affiliated with Ben Gurion University, Beersheba, Israel.
Hanna BernstineDepartment of Nuclear Medicine, Assuta Medical Center, Faculty of Medicine, Tel Aviv. Affiliated with Ben Gurion University, Beersheba, Israel.
David GrosharDepartment of Nuclear Medicine, Assuta Medical Center, Faculty of Medicine, Tel Aviv. Affiliated with Ben Gurion University, Beersheba, Israel.
Ofer AzoulayA. R. M. Center of Otolaryngology, Head and Neck Surgery, Department of Otolaryngology, Head and Neck Surgery, Assuta Medical Center, Faculty of Medicine, Tel Aviv. Affiliated with Ben Gurion University, 20 Habarzel St., 69710, Beersheba, Israel.
Yehudit LockmanDepartment of Nuclear Medicine, Assuta Medical Center, Faculty of Medicine, Tel Aviv. Affiliated with Ben Gurion University, Beersheba, Israel.
Assuta Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePreoperative localization of a parathyroid adenoma is usually obtained by the combination of ultrasound and scintigraphy with technetium-99m methoxyisobutylisonitrile. We evaluated the role of F18-fluorocholine in neck positron emission tomography/magnetic resonance imaging as a novel tool for localizing parathyroid adenomas.

methodsPatients with primary hyperparathyroidism were recruited from February 2016 to August 2017 and F18-fluorocholine positron emission tomography/magnetic resonance imaging was performed to localize the parathyroid adenoma prior to surgery. We compared sensitivity and accuracy of this modality with ultrasound and technetium-99m methoxyisobutylisonitrile scintigraphy using the verified location of the diseased parathyroid as found in surgery.

resultsNineteen patients were included in our study (15 women and 4 men, mean age 60.5 ± 9.8 years). Positron emission tomography/magnetic resonance imaging precisely localized the pathologic parathyroid gland in 16/19 cases (84.2%) and predicted the diseased side in 19/19 cases (100%). Ultrasound and technetium 99 m methoxyisobutylisonitrile sestamibi scintigraphy predicted the location of the parathyroid adenoma in 16/19 (84.2%) and 14/19 (74%), respectively. In 3/19 patients, positron emission tomography/magnetic resonance imaging localized the parathyroid adenoma where as other modalities failed. Positron emission tomography/magnetic resonance imaging was more accurate when compared to each modality separately (p < 0.001, p = 0.017), however, when comparing the three modalities all together no differences were found (p = 0.506).

conclusionsLocalizing parathyroid adenomas with F18-fluorocholine positron emission tomography/magnetic resonance imaging may be a promising secondary imaging modality.

Indexed as

RadiopharmaceuticalsAdenomaAdultAgedCholineFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedMultimodal ImagingParathyroid NeoplasmsPositron-Emission TomographyCholinefluorocholineRadiopharmaceuticalsAdenomaParathyroid localizationPositron emission tomography/magnetic resonance imagingTechnetium 99 m sestamibiUltrasound

Identifiers

PMID30877424
OpenAlexW2921375319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.