ArticleLangenbeck's archives of surgery2019
Malignancies associated with GIST: a retrospective study with molecular analysis of KIT and PDGFRA.
Article in Langenbeck's archives of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- The association of genitourinary cancer among Saudi patients with gastrointestinal stromal tumors and a systematic literature review.Scientific reports · 2023Pooled it
- Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia.World journal of gastroenterology · 2019Pooled it
- Paired tumor-normal targeted sequencing supports clonal independence of multiple primary malignancies in patients with gastrointestinal stromal tumors.International journal of clinical oncology · 2026Article
- New C3H KitScientific reports · 2022Article
- A novel fusion between CDC42BPB and ALK in a patient with quadruple wild-type gastrointestinal stromal tumor.Molecular genetics & genomic medicine · 2022Article
- Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience.Medicina (Kaunas, Lithuania) · 2021Article
- Mutational characteristics of gastrointestinal stromal tumors: A single-center analysis of 302 patients.Oncology letters · 2021Article
- Genetic Characterization of Molecular Targets in Korean Patients with Gastrointestinal Stromal Tumors.Journal of gastric cancer · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGastrointestinal stromal tumors (GISTs) are the most common soft tissue tumors of the GI tract. Studies have been published reporting additional neoplasms in GIST patients. This study aimed to evaluate possible associations of mutation type, morphology, and clinical aspects of GISTs.
methodsAll cases of GIST were identified from our pathology files. Coding exons of KIT and PDGFRA in GISTs with additional malignancies were sequenced.
resultsA total of 70 of 188 (37%) retrieved patients with confirmed diagnosis of GIST showed at least one additional malignant neoplasm. Fifty of these GISTs were located in the stomach (71%), 8 in the small intestine (11%), 5 in the colon/rectum (7%), and 7 cases (6.2%) were of undetermined sites of origin. The distribution of identified mutations was similar to that described in GISTs without secondary malignancies. A total of 37 of 57 cases (65%) showed mutations in the KIT gene exon 11, 3 (5%) cases in exon 9, and 1 (2%) case in exon 13. Nine tumors (16%) had mutations of the PDGFRA gene. KIT and PDGFRA wild-type status were found in seven cases (12%). Most of the secondary neoplasms were located within the GI tract (34%), in the urogenital system (24%), or the breast/female genital tract (20%).
conclusionThis study confirms the high rate of additional malignant tumors in GIST patients. GIST features in these cases are very similar to those with sole GIST.
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