ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2019
A more flattened bone tunnel has a positive effect on tendon-bone healing in the early period after ACL reconstruction.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Tissue Engineering Scaffold in Tendon Bone HealingFrontiers in bioengineering and biotechnology · 2021Pooled it
- Platelet-rich plasma cues program M2 macrophage-derived exosome mimetics to regenerate the tendon-bone interface.Journal of nanobiotechnology · 2026Article
- A flat posterior cruciate ligament reconstruction restores native knee kinematics, comparable to a double-bundle reconstruction-A biomechanical robotic investigation.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Superior Fulcrum Reconstruction for Massive Irreparable Rotator Cuff Tears Using the Peroneus Longus Tendon in 2 Variations: A Cadaveric Static Biomechanical Study.Orthopaedic journal of sports medicine · 2025Article
- Superior fulcrum reconstruction improve tendon-to-bone healing in irreparable massive rotator cuff tears compared with superior capsule reconstruction.Scientific reports · 2025Article
- Allogenic Achilles-tendon-bone grafts enable more complete restoration of the native direct enthesis structure in the repair of chronic massive rotator cuff tears.Frontiers in bioengineering and biotechnology · 2025Article
- Article
- A Flat Reconstruction of the Medial Collateral Ligament and Anteromedial Structures Restores Native Knee Kinematics: A Biomechanical Robotic Investigation.The American journal of sports medicine · 2024Article
- Modified Anatomical Anterior Cruciate Ligament Reconstruction with Flat Semitendinosus Graft and C-shaped Tibial Canal.Arthroscopy techniques · 2024Article
- Effect of anteromedial portal location on femoral tunnel inclination, length, and location in hamstring autograft-based single-bundle anterior cruciate ligament reconstruction: a prospective study.Knee surgery & related research · 2023Article
- Increased ACL direct insertion coverage provided more positive biomechanical effects on graft and bone tunnel during knee flexion: a simulation study.Journal of experimental orthopaedics · 2023Article
- Reconstruction of the anterior cruciate ligament: a historical view.Annals of translational medicine · 2023Review
- Current trends in graft choice for anterior cruciate ligament reconstruction - part I: anatomy, biomechanics, graft incorporation and fixation.Journal of experimental orthopaedics · 2023Article
- Strategies to promote tendon-bone healing after anterior cruciate ligament reconstruction: Present and future.Frontiers in bioengineering and biotechnology · 2023Review
- BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1/M2 macrophage polarization in rats.Stem cell research & therapy · 2022Article
- Minimizing the risk of graft failure after anterior cruciate ligament reconstruction in athletes. A narrative review of the current evidence.Journal of experimental orthopaedics · 2022Review
- Better Coverage of the ACL Tibial Footprint and Less Injury to the Anterior Root of the Lateral Meniscus Using a Rounded-Rectangular Tibial Tunnel in ACL Reconstruction: A Cadaveric Study.Orthopaedic journal of sports medicine · 2022Article
- MCL Reconstruction Using a Flat Tendon Graft for Anteromedial and Posteromedial Instability.Arthroscopy techniques · 2022Article
- Single-Tunnel Double-Bundle-Like Effect With Footprint Enhancing Anterior Cruciate Ligament Reconstruction.Arthroscopy techniques · 2022Article
- Skeletally immature patient showed lower graft maturity than skeletally mature patient after ACL reconstruction with a rounded rectangular femoral tunnel.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeThe purpose of this study was to evaluate whether a flattened bone tunnel has a positive effect on the tendon-bone healing (TBH) process in the early period after anterior cruciate ligament (ACL) reconstruction.
methodsSeventy-two New Zealand White rabbits were randomly allocated into two groups, the flattened tunnel (FT) group and the conventional round tunnel (RT) group. We compared the cross-sectional areas and diameters of the bone tunnels between the two groups through computed tomography (CT) scanning. TBH results between the two groups were assessed by histological analysis, micro-CT scanning and biomechanical tests at 4 weeks, 8 weeks and 12 weeks after operation.
resultsThe cross-sectional areas of the bone tunnels between the two groups were almost the same. However, the shape of bone tunnels in the FT group was more flattened. A faster cellular and collagen remoulding process were found in the FT group. Semiquantitative histological analysis of Safranin O staining showed that there was more fibrocartilage formation in the interface region in the FT group (P < 0.05). Sirius Red staining showed that the tissues in the interface areas were more intense in the FT group. Micro-CT scanning showed that more new bone formation could be found in the interface region in the FT group. The biomechanical tests also showed that FT ACL reconstruction will result in a stronger regenerated tendon-bone interface.
conclusionsOur study found that a flattened bone tunnel accelerated TBH in the early period after ACL reconstruction surgery in a rabbit model, which lays the groundwork for further clinical practice of this ACL reconstruction method.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.