Evidence map›Paper›PMID 30877181›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019

A Dual-Modality Linker Enables Site-Specific Conjugation of Antibody Fragments for

Kirstin A Zettlitz, Christopher M Waldmann, Wen-Ting K Tsai, Richard Tavaré, Jeffrey Collins, Jennifer M Murphy, Anna M Wu

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Review
  3. Reengineered Anti-CD4 Cys-diabody Variants forMolecular imaging and biology · 2025
    Article
  4. Article
  5. Article
  6. SyntheticRSC medicinal chemistry · 2024
    Review
  7. Review
  8. Review
  9. ClickablePharmaceuticals (Basel, Switzerland) · 2022
    Article
  10. Article
  11. Site-Specific and Residualizing Linker forJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  12. Synthesis and ComparativeBioconjugate chemistry · 2021
    Article
  13. Contemporary Approaches for Site-Selective Dual Functionalization of Proteins.Angewandte Chemie (International ed. in English) · 2021
    Review
  14. Development of anFrontiers in immunology · 2021
    Article
  15. Near-infrared fluorescence imaging in immunotherapy.Advanced drug delivery reviews · 2020
    Review
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kirstin A ZettlitzCrump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California kzettlitz@coh.org.
Christopher M WaldmannCrump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Wen-Ting K TsaiCrump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Richard TavaréCrump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Jeffrey CollinsCrump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Jennifer M MurphyCrump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Anna M WuCrump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Institute for Molecular Medicine · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA SPORE IN PROSTATE CANCERP50CA092131 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REITER, ROBERT E · 2002 to 2023
$42.6M
Multifunctional immunoPET tracers for pancreatic and prostate cancerR01CA174294 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REITER, ROBERT E, WU, ANNA M · 2013 to 2020
$3.3M
NCI NIH HHS P30 CA016042NCI NIH HHS P50 CA092131NCI NIH HHS R01 CA174294
6 · The paper itself

Abstract

Antibody-based dual-modality (PET/fluorescence) imaging enables both presurgery antigen-specific immuno-PET for noninvasive whole-body evaluation and intraoperative fluorescence for visualization of superficial tissue layers for image-guided surgery.

Indexed as

Microscopy, FluorescencePositron-Emission TomographyAnimalsAntibodiesAntigens, NeoplasmCarbocyaninesCyclooctanesCysteineFluorescenceFluorescent DyesFluorine RadioisotopesGPI-Linked ProteinsHumansImmunoglobulin FragmentsMaleMiceAntibodiesAntigens, NeoplasmCarbocyaninescyanine dye 5CyclooctanesCysteineFluorescent DyesFluorine-18Fluorine RadioisotopesGPI-Linked ProteinsImmunoglobulin FragmentsNeoplasm ProteinsPSCA protein, humanRadiopharmaceuticals18Fclick chemistrycys-diabodyfluorescence image-guided surgery (FIGS)immuno-PET

Identifiers

PMID30877181
PMCPMC6785789
OpenAlexW2922369915

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.