Evidence map›Paper›PMID 30877150›Full record

ReviewClinical science (London, England : 1979)2019

The emerging role of sorting nexins in cardiovascular diseases.

Jian Yang, Van Anthony M Villar, Selim Rozyyev, Pedro A Jose, Chunyu Zeng

Open access · hybridAbstract readReview
In one paragraph

Review in Clinical science (London, England : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 63 citations in OpenAlex.

  1. Variation inCirculation research · 2026
    Article
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  5. Review
  6. Article
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  13. Insights of Endocytosis Signaling in Health and Disease.International journal of molecular sciences · 2023
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. New insight into increased angiotensin II type 1 receptor expression in Snx1Hypertension research : official journal of the Japanese Society of Hypertension · 2021
    Article
  20. Increased ATHypertension research : official journal of the Japanese Society of Hypertension · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jian YangDepartment of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 410020, P.R. China jianyang@hospital.cqmu.edu.cn chunyuzeng01@163.com.
Van Anthony M VillarDivision of Renal Diseases and Hypertension, Department of Medicine, and Department of Pharmacology/Physiology, The George Washington University School of Medicine and Health Sciences, Washington, DC 20052, U.S.A.
Selim RozyyevDivision of Renal Diseases and Hypertension, Department of Medicine, and Department of Pharmacology/Physiology, The George Washington University School of Medicine and Health Sciences, Washington, DC 20052, U.S.A.
Pedro A JoseDivision of Renal Diseases and Hypertension, Department of Medicine, and Department of Pharmacology/Physiology, The George Washington University School of Medicine and Health Sciences, Washington, DC 20052, U.S.A.
Chunyu ZengDepartment of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing 400042, P.R. China jianyang@hospital.cqmu.edu.cn chunyuzeng01@163.com.ORCID 0000-0003-0173-5028
George Washington University · USArmy Medical University · CN

Funding

Spatiotemporal transregulation of D1-like angiotensin receptors in genetically...P01HL074940 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GILDEA, JOHN JOSEPH · 2004 to 2020
$31.8M
RENAL DOPAMINE-1 RECEPTOR DEFECT IN HYPERTENSIONR01DK039308 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI JOSE, PEDRO A. · 1987 to 2020
$7.4M
GRK4 & Development of Salt SensitivityR01HL092196 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI ARMANDO, INES, JOSE, PEDRO A. · 2008 to 2017
$3.6M
NHLBI NIH HHS P01 HL074940NHLBI NIH HHS R01 HL092196NIDDK NIH HHS R01 DK039308
6 · The paper itself

Abstract

The sorting nexin (SNX) family consists of a diverse group of cytoplasmic- and membrane-associated phosphoinositide-binding proteins that play pivotal roles in the regulation of protein trafficking. This includes the entire endocytic pathway, such as endocytosis, endosomal sorting, and endosomal signaling. Dysfunctions of SNX pathway are involved in several forms of cardiovascular disease (CVD). Moreover, SNX gene variants are associated with CVDs. In this review, we discuss the current knowledge on SNX-mediated regulatory mechanisms and their roles in the pathogenesis and treatment of CVDs.

Indexed as

AnimalsCardiovascular DiseasesCardiovascular SystemEndocytosisEndosomesHumansPrognosisProtein TransportSignal TransductionSorting NexinsSorting NexinsCardiovascular diseasesEndosomal sortingPharmacogenomicsRetromerSorting nexin

Identifiers

PMID30877150
PMCPMC6418407
OpenAlexW2921179399

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.