Evidence map›Paper›PMID 30877122›Full record

ArticleApplied and environmental microbiology2019

Enterobactin-Specific Antibodies Induced by a Novel Enterobactin Conjugate Vaccine.

Huiwen Wang, Ximin Zeng, Yiming Mo, Bin He, Hening Lin, Jun Lin

Open access · bronzeAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Staphylococcal mastitis in dairy cows.Frontiers in veterinary science · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Frontiers in immunology · 2021
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Huiwen WangDepartment of Animal Science, The University of Tennessee, Knoxville, Tennessee, USA.
Ximin ZengDepartment of Animal Science, The University of Tennessee, Knoxville, Tennessee, USA.
Yiming MoDepartment of Animal Science, The University of Tennessee, Knoxville, Tennessee, USA.
Bin HeDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA.
Hening LinDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA.
Jun LinDepartment of Animal Science, The University of Tennessee, Knoxville, Tennessee, USA jlin6@utk.edu.
University of Tennessee at Knoxville · USCornell University · US

Funding

Enterobactin-mediated iron acquisition for Campylobacter infectionR21AI119462 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI LIN, JUN · 2016 to 2017
$371k
NIAID NIH HHS R21 AI119462
6 · The paper itself

Abstract

Enterobactin (Ent)-mediated high-affinity iron acquisition is critical for Gram-negative bacteria to survive in the host. Given the bacteriostatic effect of lipocalin resulting from its potent Ent-binding ability, immune intervention directly targeting Ent is promising for iron-dependent pathogen control. Recently, an Ent conjugate vaccine was reported, but it still has several significant weaknesses. In this study, we sought to develop an innovative Ent conjugate vaccine that can induce a high level of antibodies directed against Ent and to provide solid evidence demonstrating siderophore-binding capacity of Ent-specific antibodies. Using a simple method, we successfully conjugated purified Ent to different carriers, including keyhole limpet hemocyanin (KLH), bovine serum albumin, and CmeC, a vaccine candidate for

Indexed as

AnimalsAntibodies, BacterialBacterial VaccinesCampylobacter coliCampylobacter jejuniEnterobactinRabbitsVaccines, ConjugateAntibodies, BacterialBacterial VaccinesEnterobactinVaccines, Conjugateconjugate vaccineenterobactinlipocalinsalmochelin

Identifiers

PMID30877122
PMCPMC6498152
OpenAlexW2921833537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.