Evidence map›Paper›PMID 30877107›Full record

ArticleCancer research2019

MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment.

Konstantinos Zormpas-Petridis, Neil P Jerome, Matthew D Blackledge, Fernando Carceller, Evon Poon, Matthew Clarke, Ciara M McErlean, Giuseppe Barone, Alexander Koers, Sucheta J Vaidya and 11 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 3 countries.

Konstantinos Zormpas-PetridisDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.
Neil P JeromeDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.
Matthew D BlackledgeDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.
Fernando CarcellerDivision of Clinical Studies, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.
Evon PoonDivision of Clinical Studies, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.
Matthew ClarkeDivision of Molecular Pathology, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.
Ciara M McErleanDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.
Giuseppe BaroneDepartment of Pediatric Oncology, Great Ormond Street Hospital for Children, London, United Kingdom.
Alexander KoersDivision of Clinical Studies, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.
Sucheta J VaidyaDivision of Clinical Studies, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.
Lynley V MarshallDivision of Clinical Studies, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.
Andrew D J PearsonDivision of Clinical Studies, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.
Lucas MorenoClinical Research Unit, Pediatric Oncology, Hematology and Stem Cell Transplant Department, Hospital Infantil Universitario Ninõ Jesús, Madrid, Spain.ORCID 0000-0002-0708-1670
John AndersonDepartment of Pediatric Oncology, Great Ormond Street Hospital for Children, London, United Kingdom.
Neil SebireUCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Kieran McHughDepartment of Radiology, Great Ormond Street Hospital for Children, London, United Kingdom.
Dow-Mu KohDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.ORCID 0000-0001-7654-8011
Yinyin YuanDivision of Molecular Pathology, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.
Louis CheslerDivision of Clinical Studies, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.ORCID 0000-0001-7842-2068
Simon P RobinsonDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.ORCID 0000-0003-4101-7274
Yann JaminDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London and The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom. yann.jamin@icr.ac.uk.
Royal Marsden NHS Foundation Trust · GBInstitute of Cancer Research · GBGreat Ormond Street Hospital · GBHospital Infantil Universitario Niño Jesús · ES

Funding

Cancer Research UK 16464Cancer Research UK 18339Cancer Research UK 27725Cancer Research UK A10334Cancer Research UK A14610Cancer Research UK A16464Cancer Research UK A18339Department of Health
6 · The paper itself

Abstract

Childhood neuroblastoma is a hypervascular tumor of neural origin, for which antiangiogenic drugs are currently being evaluated; however, predictive biomarkers of treatment response, crucial for successful delivery of precision therapeutics, are lacking. We describe an MRI-pathologic cross-correlative approach using intrinsic susceptibility (IS) and susceptibility contrast (SC) MRI to noninvasively map the vascular phenotype in neuroblastoma Th-MYCN transgenic mice treated with the vascular endothelial growth factor receptor inhibitor cediranib. We showed that the transverse MRI relaxation rate

Indexed as

Angiogenesis InhibitorsAnimalsChildChild, PreschoolContrast MediaFemaleHumansIndolesInfantMagnetic Resonance ImagingMaleMice, TransgenicNeoplasms, ExperimentalNeuroblastomaN-Myc Proto-Oncogene ProteinProspective StudiesAngiogenesis InhibitorscediranibContrast MediaIndolesMYCN protein, humanN-Myc Proto-Oncogene ProteinProtein Kinase InhibitorsQuinazolines

Identifiers

PMID30877107
PMCPMC6558276
OpenAlexW2921045130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.