ArticleCancer research2019
Combined Menin and EGFR Inhibitors Synergize to Suppress Colorectal Cancer via EGFR-Independent and Calcium-Mediated Repression of SKP2 Transcription.
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Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Cascade-responsive HA-decorated liposome/mesoporous silica nanoplatform co-delivering BMF-219 and 5-FU enhances gastric cancer chemotherapy through Menin- and p53-associated apoptotic signaling.Journal of experimental & clinical cancer research : CR · 2026Article
- Hsa-miR-149-5p targets Men1 to inhibit the progression of gastric cancer through the HSPA6/JNK pathway.Cancer cell international · 2026Article
- SKP2 in Cancer: From Molecular Regulation to Therapeutic Vulnerabilities and Translational Perspectives.Drug design, development and therapy · 2026Review
- Exosome-derived Menin from cancer-associated fibroblasts promotes gastric cancer progression by activating the HSPA6/JNK/JunD pathway and inducing EMT.Journal of translational medicine · 2025Article
- PTH1R Suppressed Apoptosis of Mesenchymal Progenitors in Mandibular Growth.International journal of molecular sciences · 2024Article
- Menin in Cancer.Genes · 2024Review
- Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling.Cell reports. Medicine · 2024Article
- Establishment of a novel microfluidic co-culture system for simultaneous analysis of multiple indicators of gefitinib sensitivity in colorectal cancer cells.Mikrochimica acta · 2024Article
- Menin Maintains Cholesterol Content in Colorectal Cancer via Repression of LXR-Mediated Transcription.Cancers · 2023Article
- Small-molecule compounds inhibiting S-phase kinase-associated protein 2: A review.Frontiers in pharmacology · 2023Review
- Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization.Developmental cell · 2022Article
- The Prognostic and Molecular Landscape of Autophagy-Related Long Noncoding RNA in Colorectal Cancer.BioMed research international · 2022Article
- Review
- Menin-regulated Pbk controls high fat diet-induced compensatory beta cell proliferation.EMBO molecular medicine · 2021Article
- Article
- Menin-mediated Repression of Glycolysis in Combination with Autophagy Protects Colon Cancer Against Small-molecule EGFR Inhibitors.Molecular cancer therapeutics · 2020Article
- Article
- Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression.Theranostics · 2020Article
- Cdh1-mediated Skp2 degradation by dioscin reprogrammes aerobic glycolysis and inhibits colorectal cancer cells growth.EBioMedicine · 2020Article
- Menin: Expanding and dichotomous roles in cancer.Oncoscience · 2019Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 2 countries.
Bryson W KatonaDivision of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Rebecca A GlynnDepartment of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Kayla E PauloskyDepartment of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Zijie FengDepartment of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Caroline I DavisBiochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.ORCID 0000-0002-5849-6649
Jian MaDepartment of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Corbett T BerryDepartment of Pathobiology and Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania.
Katherine M SzigetyDepartment of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Smita MatkarDepartment of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Yuanyuan LiuDepartment of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Haoren WangDepartment of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Yuan WuDepartment of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Xin HeDepartment of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Bruce D FreedmanDepartment of Pathobiology and Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania.
Donita C BradyDepartment of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.ORCID 0000-0002-2786-2802
Xianxin HuaDepartment of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. huax@pennmedicine.upenn.edu.
UPMC Hillman Cancer Center · USUniversity of Pennsylvania · USDrexel University · US
Funding
TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI REBECCA G WELLS · 1997 to 2026
$32.5MTRAINING PROGRAM IN CELL AND MOLECULAR BIOLOGYT32GM007229 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 1985 to 2023
$14.0MMolecular and Cellular Mechanisms of Copper-Dependent Nutrient Signaling and MetabolismR35GM124749 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Donita C Brady · 2017 to 2026
$4.6MMenin-mediated epigenetic tumor suppressionR01CA178856 · NCI · UNIVERSITY OF PENNSYLVANIA · PI HUA, XIANXIN · 2014 to 2018
$1.7MBeta Cell Regeneration by an Epigenetic PathwayR01DK097555 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI HUA, XIANXIN · 2013 to 2016
$1.4MMenin/MLL promotes cell survival in the setting of EGFR inhibitionK08DK106489 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI KATONA, BRYSON WILLIAM · 2015 to 2019
$819kNCI NIH HHS R01 CA178856NIDDK NIH HHS K08 DK106489NIDDK NIH HHS P30 DK050306NIDDK NIH HHS R01 DK097555NIGMS NIH HHS R35 GM124749NIGMS NIH HHS T32 GM007229
Abstract
Menin is a nuclear epigenetic regulator that can both promote and suppress tumor growth in a highly tissue-specific manner. The role of menin in colorectal cancer, however, remains unclear. Here, we demonstrate that menin was overexpressed in colorectal cancer and that inhibition of menin synergized with small-molecule inhibitors of EGFR (iEGFR) to suppress colorectal cancer cells and tumor xenografts
Indexed as
Drug SynergismAnimalsApoptosisBiomarkers, TumorCalciumCell ProliferationColorectal NeoplasmsDrug Therapy, CombinationEnzyme InhibitorsErbB ReceptorsFemaleGefitinibGene Expression Regulation, NeoplasticHumansInositol 1,4,5-Trisphosphate ReceptorsMiceBiomarkers, TumorCalciumEGFR protein, humanEnzyme InhibitorsErbB ReceptorsGefitinibInositol 1,4,5-Trisphosphate ReceptorsITPR3 protein, humanMEN1 protein, humanProtein Kinase InhibitorsProto-Oncogene ProteinsSKP2 protein, humanS-Phase Kinase-Associated ProteinsThapsigargin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.