ArticleBone2019
Ultrashort echo time magnetic resonance imaging (UTE-MRI) of cortical bone correlates well with histomorphometric assessment of bone microstructure.
Article in Bone, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 58 citations in OpenAlex.
- Design of Differential Single-Block and Multi-Block Presaturated Ultrashort Echo Time Pulse Sequences for Fast and Flexible Short-TMagnetic resonance in medicine · 2026Article
- Bicomponent Mapping of Cortical Bone Using a New Interleaved UTE Imaging Sequence.Magnetic resonance in medicine · 2026Article
- Entheseal bone remodeling and patient reported outcomes in osteoarthritis - A quantitative [18F]NaF-PET MRI study.Osteoarthritis and cartilage · 2025Observational
- Current Landscape of Short-T2 Imaging Techniques in the Musculoskeletal System: The Past, Present and Future.Journal of magnetic resonance imaging : JMRI · 2025Review
- Accelerated ultrashort echo time quantitative magnetization transfer (UTE-qMT) imaging of macromolecular fraction (MMF) in cortical bone based on a self-attention convolutional neural network.Magnetic resonance imaging · 2025Article
- Black bone and CT-like MRI-based delineation of fracture-prone regions in oral and maxillofacial trauma.Oral and maxillofacial surgery · 2025Article
- UTE MRI technical developments and applications in osteoporosis: a review.Frontiers in endocrinology · 2025Review
- Significant age-related differences between lower leg muscles of older and younger female subjects detected by ultrashort echo time magnetization transfer modeling.NMR in biomedicine · 2024Article
- Ultrashort echo time MRI detects significantly lower collagen but higher pore water in the tibial cortex of female patients with osteopenia and osteoporosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Ultrasound attenuation of cortical bone correlates with biomechanical, microstructural, and compositional properties.European radiology experimental · 2024Article
- Bone Biomarkers Based on Magnetic Resonance Imaging.Seminars in musculoskeletal radiology · 2024Review
- Differentiation of histological calcification classifications in breast cancer using ultrashort echo time and chemical shift-encoded imaging MRI.Frontiers in oncology · 2024Article
- Relationship between CT-Derived Bone Mineral Density and UTE-MR-Derived Porosity Index in Equine Third Metacarpal and Metatarsal Bones.Animals : an open access journal from MDPI · 2023Article
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- Robust Assessment of Macromolecular Fraction (MMF) in Muscle with Differing Fat Fraction Using Ultrashort Echo Time (UTE) Magnetization Transfer Modeling with Measured T1.Diagnostics (Basel, Switzerland) · 2023Article
- Ultra-short TMagnetic resonance in medicine · 2023Article
- MRI-based porosity index (PI) and suppression ratio (SR) in the tibial cortex show significant differences between normal, osteopenic, and osteoporotic female subjects.Frontiers in endocrinology · 2023Article
- Making the invisible visible-ultrashort echo time magnetic resonance imaging: Technical developments and applications.Applied physics reviews · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Ultrashort echo time magnetic resonance imaging (UTE-MRI) techniques have been increasingly used to assess cortical bone microstructure. High resolution micro computed tomography (μCT) is routinely employed for validating the MRI-based assessments. However, water protons in cortical bone may reside in micropores smaller than the detectable size ranges by μCT. The goal of this study was to evaluate the upper limit of UTE-MRI and compare its efficacy to μCT at determining bone porosity ex vivo. This study investigated the correlations between UTE-MRI based quantifications and histomorphometric measures of bone porosity that cover all pores larger than 1 μm. Anterior tibial midshaft specimens from eleven donors (51 ± 16 years old, 6 males, 5 females) were scanned on a clinical 3 T-MRI using UTE magnetization transfer (UTE-MT, three power levels and five frequency offsets) and UTE-T2* sequences. Two-pool MT modeling and bi-component exponential T2* fitting were performed on the MRI datasets. Specimens were then scanned by μCT at 9 μm voxel size. Histomorphometry was performed on hematoxylin and eosin (H&E) stained slides imaged at submicron resolution. Macromolecular fraction from MT modeling, bi-component T2* fractions, and short component T2* showed strong correlations (R > 0.7, p < 0.01) with histomorphometric total and large-pores (>40 μm) porosities as well as with μCT-based porosity. UTE-MRI could also assess small pores variations with moderate correlations (R > 0.5, p < 0.01). The UTE-MRI techniques can detect variations of bone porosity comprised of pores below the range detectable by μCT. Such fine pore variations can contribute differently to the development of bone diseases or to the bone remodeling process, however, this needs to be investigated. In scanned specimens, major porosity changes were from large pores, therefore the μCT employment was likely adequate to validate UTE-MRI biomarkers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.