Evidence map›Paper›PMID 30876849›Full record

ArticleNeuron2019

Retinoic Acid Induces Hyperactivity, and Blocking Its Receptor Unmasks Light Responses and Augments Vision in Retinal Degeneration.

Michael Telias, Bristol Denlinger, Zachary Helft, Casey Thornton, Billie Beckwith-Cohen, Richard H Kramer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 57 citations in OpenAlex.

  1. Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Bridging the gap of vision restoration.Frontiers in cellular neuroscience · 2024
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Bioengineering strategies for restoring vision.Nature biomedical engineering · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Michael TeliasDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Bristol DenlingerDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Zachary HelftDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Vision Science Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA.
Casey ThorntonDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Billie Beckwith-CohenDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Vision Science Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA.
Richard H KramerDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Vision Science Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: rhkramer@berkeley.edu.
University of California, Berkeley · US

Funding

UC Berkeley Vision Science COREP30EY003176 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RICHARD H KRAMER · 1985 to 2026
$16.4M
Photoswitchable channel blockers for treatment of blindnessR24EY023937 · NEI · UNIVERSITY OF WASHINGTON · PI VAN GELDER, RUSSELL N. · 2014 to 2018
$6.1M
Understanding how photoswitches restore visual function in blindnessR01EY024334 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI KRAMER, RICHARD H · 2015 to 2024
$4.4M
Probing GABAa receptor function and plasticity with lightR01NS100911 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI KRAMER, RICHARD H · 2017 to 2020
$1.8M
NEI NIH HHS P30 EY003176NEI NIH HHS R01 EY024334NEI NIH HHS R24 EY023937NINDS NIH HHS R01 NS100911
6 · The paper itself

Abstract

Light responses are initiated in photoreceptors, processed by interneurons, and synaptically transmitted to retinal ganglion cells (RGCs), which send information to the brain. Retinitis pigmentosa (RP) is a blinding disease caused by photoreceptor degeneration, depriving downstream neurons of light-sensitive input. Photoreceptor degeneration also triggers hyperactive firing of RGCs, obscuring light responses initiated by surviving photoreceptors. Here we show that retinoic acid (RA), signaling through its receptor (RAR), is the trigger for hyperactivity. A genetically encoded reporter shows elevated RAR signaling in degenerated retinas from murine RP models. Enhancing RAR signaling in healthy retinas mimics the pathophysiology of degenerating retinas. Drug inhibition of RAR reduces hyperactivity in degenerating retinas and unmasks light responses in RGCs. Gene therapy inhibition of RAR increases innate and learned light-elicited behaviors in vision-impaired mice. Identification of RAR as the trigger for hyperactivity presents a degeneration-dependent therapeutic target for enhancing low vision in RP and other blinding disorders.

Indexed as

Vision, OcularAnimalsCell Membrane PermeabilityDisease Models, AnimalElectroencephalographyGenetic TherapyHEK293 CellsHumansMicePatch-Clamp TechniquesPhotosensitivity DisordersRatsReceptors, Retinoic AcidRetinal DegenerationRetinal Ganglion CellsRetinitis PigmentosaReceptors, Retinoic AcidTretinoinblindnessdrug targetgene therapylight sensitivityneural hyperactivityretinal degenerationretinitis pigmentosaretinoic acidretinoic acid receptor

Identifiers

PMID30876849
PMCPMC6508985
OpenAlexW2922467843

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.