ArticleGynecologic oncology2019
Comparison of patient reported symptom burden on an enhanced recovery after surgery (ERAS) care pathway in patients with ovarian cancer undergoing primary vs. interval tumor reductive surgery.
Article in Gynecologic oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Endoscopic endonasal approach vs microsurgical transcranial approach in intracranial chordoma surgery: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Data Quality of Longitudinally Collected Patient-Reported Outcomes After Thoracic Surgery: Comparison of Paper- and Web-Based Assessments.Journal of medical Internet research · 2021Trial
- Review
- Patient-reported symptom burden and circulating cytokines undergoing chemotherapy: a pilot study in patients with ovarian cancer.Journal of gynecologic oncology · 2025Article
- Bibliometric analysis of multimodal analgesia research in the perioperative period: trends, contributions, and emerging areas (2013-2023).Frontiers in medicine · 2025Article
- Patient-reported nausea after implementation of an enhanced recovery after surgery protocol for gynae-oncology patients.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023Article
- Patient-reported symptoms at discharge and risk of complications after gynecologic surgery.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023Article
- Risk factors of perioperative complications and management with enhanced recovery after primary surgery in women with epithelial ovarian carcinoma in a single center.Oncology letters · 2022Article
- Patient-reported outcomes: Is this the missing link in patient-centered perioperative care?Best practice & research. Clinical anaesthesiology · 2021Review
- Assessment of physical function by subjective and objective methods in patients undergoing open gynecologic surgery.Gynecologic oncology · 2021Article
- Patient-Reported Outcomes in Surgical Oncology: An Overview of Instruments and Scores.Annals of surgical oncology · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo compare symptom burden and functional recovery in women undergoing primary cytoreductive surgery (PCS) or neoadjuvant chemotherapy (NACT) and interval cytoreductive surgery (ICS) within an enhanced recovery after surgery program (ERAS).
methodsSymptom burden was measured using the MD Anderson Symptom Inventory-Ovarian Cancer, a 27-item validated tool that was administered preoperatively, daily while hospitalized, and weekly for 8 weeks after hospital discharge. Mixed-effect modeling was performed.
results196 patients (71 PCS, 125 ICS) participated. Patients in the PCS group were younger, median age of 59 vs. 63 in ICS group. Median length of stay was 4 days for PCS and 3 days for ICS group. PCS pts had a significantly higher median surgical complexity score (4 vs. 2, p = 0.002), and longer median surgical time (257 min vs. 220 min, p = 0.03). While patients undergoing PCS had significantly different symptom burden profiles prior to surgery compared to those undergoing ICS, there were no significant differences in symptoms in the immediate in-hospital and extended post-hospital discharge period. Irrespective of the timing of surgery in relation to chemotherapy, patients undergoing intermediate or high complexity surgery had more nausea, fatigue, and higher total interference scores compared to patients undergoing low complexity surgery.
conclusionWithin a center with a standardized, systematic method for patient selection for PCS and a standardized ERAS care pathway, there were not significant differences in surgery-related symptoms related to recovery between patients undergoing PCS or ICS. However, patient-reported symptom burden and symptom interference did meaningfully differentiate based on surgical complexity score.
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