Evidence map›Paper›PMID 30876469›Full record

ArticleBMC public health2019

Study protocol of a pragmatic randomized controlled trial incorporated into the Group Lifestyle Balance™ program: the nutrigenomics, overweight/obesity and weight management trial (the NOW trial).

Justine Horne, Jason Gilliland, Colleen O'Connor, Jamie Seabrook, Peter Hannaberg, Janet Madill

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03015012 (Using Personalized Nutrigenomics Testing to Mitigate Overweight/Obesity Risk in Two Distinct Patient Populations), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03015012 naunknown statusnot on this map

Using Personalized Nutrigenomics Testing to Mitigate Overweight/Obesity Risk in Two Distinct Patient Populations: A Multicentre Randomized Clinical Intervention Trial

TypeinterventionalSponsorWestern University, CanadaRan2017 to 2020Enrolled200ConditionsTransplant-Related Disorder, Overweight and ObesityArmsPersonalized Nutrigenomics Testing (PNT), Standard Nutrition Intervention (SNI)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Personalised nutrition technologies: a new paradigm for dietetic practice and training in a digital transformation era.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2020
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Justine HorneHealth and Rehabilitation Sciences, The University of Western Ontario, London, ON, Canada. jhorne5@uwo.ca.
Jason GillilandHuman Environments Analysis Laboratory, The University of Western Ontario, London, ON, Canada.
Colleen O'ConnorSchool of Food and Nutritional Sciences, Brescia University College at The University of Western Ontario, London, ON, Canada.
Jamie SeabrookSchool of Food and Nutritional Sciences, Brescia University College at The University of Western Ontario, London, ON, Canada.
Peter HannabergSchool of Food and Nutritional Sciences, Brescia University College at The University of Western Ontario, London, ON, Canada.
Janet MadillSchool of Food and Nutritional Sciences, Brescia University College at The University of Western Ontario, London, ON, Canada.
Western University · CA

Funding

Canadian Institutes of Health Research 395167
6 · The paper itself

Abstract

backgroundThe nutrigenomics, overweight/obesity and weight management trial (NOW Trial) is a pragmatic randomized controlled trial of community-dwelling adults recruited from the Group Lifestyle Balance™ (GLB™) Program. The GLB™ Program (formerly referred to as the Diabetes Prevention Program) is an evidence-based, intensive weight management program, which was offered to overweight/obese patients (BMI ≥ 25.0 kg/m

methodsPatients enrolled in the GLB™ Program were invited to participate in this study. GLB™ groups were randomized 1:1 to receive either the standard GLB™ program + population-based lifestyle advice for weight management, or a modified GLB™ program + personalized, genetic-based lifestyle advice for weight management. The purpose of this study is to determine if the provision of genetic-based lifestyle guidelines is superior to the provision of population-based guidelines in a pragmatic clinical setting to promote changes in: body composition, weight, body mass index, dietary and physical activity habits, as well as attitudes, subjective norms, and behavioural control. The 12-month intervention protocol consists of 23 group-based sessions and 4 one-on-one sessions. Data collection time points include baseline in addition to 3, 6, and 12-month follow up. The comprehensive study design is described in the present manuscript, using both the extended CONSORT checklist for reporting pragmatic trials and the SPIRIT checklist as guidance during manuscript development. DISCUSSION: Overall, this study seeks to pragmatically determine if the provision of DNA-based lifestyle advice leads to improved health and lifestyle outcomes compared to the provision of standard, population-based lifestyle advice. The results of this trial can be used to inform clinical and community nutrition practice guidelines.

trial registrationThis study was registered with clinicaltrials.gov : NCT03015012 on January 9, 2017.

Indexed as

Genetic CounselingLife StyleNutrigenomicsOverweightWeight Reduction ProgramsAdultHumansObesityOntarioPragmatic Clinical Trials as TopicProgram EvaluationRandomized Controlled Trials as TopicResearch DesignRural PopulationGeneticsLifestyle genomicsNutrigeneticsNutrigenomicsNutritionObesityOverweightPhysical activity

Identifiers

PMID30876469
PMCPMC6419841
OpenAlexW2940189362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.