Observational studyCardiovascular diabetology2019
Type 2 diabetes mellitus increases long-term mortality risk after isolated surgical aortic valve replacement.
Observational study in Cardiovascular diabetology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Type 2 diabetes is associated with clinical progression of aortic stenosis: a nationwide retrospective study in Sweden.Scientific reports · 2026Article
- The effect of diabetes mellitus on aortic valve stenosis and its treatment outcome: A meta-analysis review.ARYA atherosclerosis · 2026Review
- Diabetes Mellitus Type 2 and Coronary Artery Bypass Grafting: Elevated Risks of Mortality and Postoperative Complications.BioMed research international · 2026Article
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- Article
- Diabetes and calcific aortic valve disease: controversy of clinical outcomes in diabetes after aortic valve replacement.Frontiers in endocrinology · 2025Review
- Prognostic effect of the TyG index on patients with severe aortic stenosis following transcatheter aortic valve replacement: a retrospective cohort study.Cardiovascular diabetology · 2024Observational
- A high-volume study on the impact of diabetes mellitus on clinical outcomes after surgical and percutaneous cardiac interventions.Cardiovascular diabetology · 2024Observational
- Current knowledge for the risk factors of early permanent pacemaker implantation following transcatheter aortic valve replacement and what is next for the primary prevention?World journal of cardiology · 2024Article
- Prognostic effect of stress hyperglycemia ratio on patients with severe aortic stenosis receiving transcatheter aortic valve replacement: a prospective cohort study.Cardiovascular diabetology · 2024Article
- Association between the insulin resistance and all-cause mortality in patients with moderate and severe aortic stenosis: a retrospective cohort study.Cardiovascular diabetology · 2023Article
- Surgical ablation for atrial fibrillation: impact of Diabetes Mellitus type 2.Cardiovascular diabetology · 2023Observational
- Systemic proinflammatory-profibrotic response in aortic stenosis patients with diabetes and its relationship with myocardial remodeling and clinical outcome.Cardiovascular diabetology · 2023Article
- Trends and Outcomes of Aortic Valve Replacement in Patients With Diabetes in the US.Frontiers in cardiovascular medicine · 2022Article
- Did blood transfusion increase mortality in patients with diabetes undergoing isolated coronary artery bypass graft surgery? A propensity score-matched analysis of 816 patients.Turk gogus kalp damar cerrahisi dergisi · 2020Article
- Type 2 diabetes mellitus increases the mortality risk after acute coronary syndrome treated with coronary artery bypass surgery.Cardiovascular diabetology · 2020Observational
- Impact of type 2 diabetes mellitus on mid-term mortality for hypertrophic cardiomyopathy patients who underwent septal myectomy.Cardiovascular diabetology · 2020Observational
- Depressed systemic arterial compliance and impaired left ventricular midwall performance in aortic stenosis with concomitant type 2 diabetes: a retrospective cross-sectional study.Cardiovascular diabetology · 2019Article
- Editorial: Cardiovascular Disease and Diabetes.Frontiers in endocrinology · 2019Article
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7 authors.
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Abstract
backgroundDiabetes mellitus (DM) adversely affects morbidity and mortality for major atherosclerosis-related cardiovascular diseases and is associated with increased risk for the development of aortic stenosis. Clinical data regarding the impact of DM on outcomes of patients undergoing aortic valve replacement (AVR) have revealed inconsistent results. The aim of the current study was to investigate and compare the impact of type 2 DM on short-, intermediate- and long-term mortality between DM and non-DM patients who undergo isolated AVR.
methodsWe performed an observational study in a large tertiary medical center over a 14-year period (2004-2018), which included all patients who had undergone isolated AVR surgery for the first time. Of the 1053 study patients, 346 patients (33%) had type 2 DM (DM group) and were compared with non-DM (non-DM group) patients (67%). Short-term (in-hospital), intermediate (1- and 3-years), and late (5- and 10-years) mortality were evaluated. Mean follow-up of was 69 ± 43 months.
resultsShort-term (in-hospital) mortality was similar between the DM compared with the non-DM group: 3.5% and 2.5% (p = 0.517). Intermediate-term mortality (1- and 3-year) was higher in the DM group compared with the non-DM group, but did not reach statistical significance: 8.1% vs. 5.7% (p = 0.169) and 12.1% vs. 8.3% (p = 0.064) respectively. Long-term (5- and 10-year) mortality was significantly higher in the DM group, compared to the non-DM group: 19.4% vs. 12.9% (p = 0.007) and 30.3% vs. 23.5% (p = 0.020) respectively. Among the 346 DM patients, 55 (16%) were treated with insulin and 291 (84%) with oral antiglycemic medication only. Overall in-hospital mortality among insulin-treated DM patients was 7.3% compared with 2.7% among non insulin-treated DM patients (p = 0.201). Long-term mortality was higher in the subgroup of insulin-treated DM patients compared with the subgroup of non-insulin treated DM patients with an overall mortality rate of 36.4% vs. 29.2% (p = 0.039). Furthermore, predictors for late mortality included DM (HR 1.39 CI 1.03-1.86, p = 0.031) and insulin treatment (HR 1.76 CI 1.05-2.94, p = 0.033), as demonstrated after adjustment for confounders by multivariable analysis.
conclusionsType 2 DM is an independent predictor for long-term mortality after isolated AVR surgery.
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