Evidence map›Paper›PMID 30876411›Full record

SynthesisRespiratory research2019

Noninvasive high-frequency oscillatory ventilation as respiratory support in preterm infants: a meta-analysis of randomized controlled trials.

Jing Li, Xiaoxia Li, Xianmei Huang, Zhiqun Zhang

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 5 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jing LiDepartment of Neonatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, China, No. 261 Huansha Road, Hangzhou City, Zhejiang, 310002, China.
Xiaoxia LiDepartment of Neonatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, China, No. 261 Huansha Road, Hangzhou City, Zhejiang, 310002, China.
Xianmei HuangDepartment of Neonatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, China, No. 261 Huansha Road, Hangzhou City, Zhejiang, 310002, China.
Zhiqun ZhangDepartment of Neonatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, China, No. 261 Huansha Road, Hangzhou City, Zhejiang, 310002, China. zhiqun.zhang@163.com.ORCID http://orcid.org/0000-0002-9068-9715
Hangzhou First People's Hospital · CN

Funding

Health and Family Planning Commission of Zhejiang Province of China 2014RCA021Natural Science Foundation of Zhejiang Province LY15H040002
6 · The paper itself

Abstract

backgroundNoninvasive high-frequency oscillatory ventilation (nHFOV), a relatively new modality, is gaining popularity despite scarce evidence. This meta-analysis was designed to evaluate the efficacy and safety of nHFOV as respiratory support in premature infants.

methodsWe searched MEDLINE, EMBASE, CINAHL, and Cochrane CENTRAL from inception of the database to January 2019. All published randomized controlled trials (RCTs) evaluating the effect of nHFOV therapy with nasal continuous positive airway pressure (nCPAP) or biphasic nCPAP (BP-CPAP) in newborns for respiratory support were included. All meta-analyses were performed using Review Manager 5.3.

resultsA total of 8 RCTs involving 463 patients were included. The meta-analysis estimated a lower risk of intubation (relative risk = 0.50, 95% confidence interval of 0.36 to 0.70) and more effective clearance of carbon dioxide (weighted mean difference = - 4.61, 95% confidence interval of - 7.94 to - 1.28) in the nHFOV group than in the nCPAP/BP-CPAP group.

conclusionsOur meta-analysis of RCTs suggests that nHFOV, as respiratory support in preterm infants, significantly remove carbon dioxide and reduce the risk of intubation compared with nCPAP/BP-CPAP. The appropriate parameter settings for different types of noninvasive high-frequency ventilators, the effect of nHFOV in extremely preterm infants, and the long-term safety of nHFOV need to be assessed in large trials.

Indexed as

Infant, PrematureHigh-Frequency VentilationHumansInfantInfant, NewbornNoninvasive VentilationRandomized Controlled Trials as TopicRespiratory Distress Syndrome, NewbornBronchopulmonary dysplasiaContinuous positive airway pressureNoninvasive high-frequency oscillatory ventilationPreterm infants

Identifiers

PMID30876411
PMCPMC6420773
OpenAlexW2921374379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.