Evidence map›Paper›PMID 30875987›Full record

ReviewNutrients2019

The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity.

Tomás Cerdó, José Antonio García-Santos, Mercedes G Bermúdez, Cristina Campoy

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 10 pooled it
28.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

179 citing papers in PubMed, 10 syntheses or guidelines pooled it, 385 citations in OpenAlex.

  1. Pooled it
  2. Biopsychosocial and Environmental Factors That Impact Brain-Gut-Microbiome Interactions in Obesity.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
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  20. Probiotics Cancer Interaction, Prevention, and Therapy.Immunity, inflammation and disease · 2026
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119 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tomás CerdóDepartment of Pediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, Spain. tcr@ugr.es.
José Antonio García-SantosDepartment of Pediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, Spain. joseantonio_gsantos@outlook.es.
Mercedes G BermúdezDepartment of Pediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, Spain. mgbermudez@ugr.es.
Cristina CampoyDepartment of Pediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, Spain. ccampoy@ugr.es.ORCID 0000-0002-9860-6785
Universidad de Granada · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a global pandemic complex to treat due to its multifactorial pathogenesis-an unhealthy lifestyle, neuronal and hormonal mechanisms, and genetic and epigenetic factors are involved. Scientific evidence supports the idea that obesity and metabolic consequences are strongly related to changes in both the function and composition of gut microbiota, which exert an essential role in modulating energy metabolism. Modifications of gut microbiota composition have been associated with variations in body weight and body mass index. Lifestyle modifications remain as primary therapy for obesity and related metabolic disorders. New therapeutic strategies to treat/prevent obesity have been proposed, based on pre- and/or probiotic modulation of gut microbiota to mimic that found in healthy non-obese subjects. Based on human and animal studies, this review aimed to discuss mechanisms through which gut microbiota could act as a key modifier of obesity and related metabolic complications. Evidence from animal studies and human clinical trials suggesting potential beneficial effects of prebiotic and various probiotic strains on those physical, biochemical, and metabolic parameters related to obesity is presented. As a conclusion, a deeper knowledge about pre-/probiotic mechanisms of action, in combination with adequately powered, randomized controlled follow-up studies, will facilitate the clinical application and development of personalized healthcare strategies.

Indexed as

ObesityPrebioticsProbioticsAnimalsHumansMicePrebioticsgut microbiotanutritionobesityprebioticsprobiotics

Identifiers

PMID30875987
PMCPMC6470608
OpenAlexW2921246494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.