Evidence map›Paper›PMID 30875983›Full record

ArticleMolecules (Basel, Switzerland)2019

Synthesis of 3-(Imidazo[2,1-

Ilaria Conti, Rita Morigi, Alessandra Locatelli, Mirella Rambaldi, Gloria Bua, Giorgio Gallinella, Alberto Leoni

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ilaria ContiDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. ilaria.conti5@unibo.it.
Rita MorigiDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. rita.morigi@unibo.it.
Alessandra LocatelliDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. alessandra.locatelli@unibo.it.
Mirella RambaldiDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. mirella.rambaldi@unibo.it.
Gloria BuaDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. gloria.bua2@unibo.it.
Giorgio GallinellaDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. giorgio.gallinella@unibo.it.ORCID 0000-0003-1118-6341
Alberto LeoniDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. alberto.leoni@unibo.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parvovirus B19 (B19V) is a human pathogenic virus associated with a wide range of clinical conditions. Currently, there are no recognized antiviral drugs for B19V treatment; therefore, efforts in the search for compounds inhibiting B19V replication are now being pursued. Coumarins (chromen-2-ones) are considered a privileged structure for designing novel orally bioavailable and non-peptidic antiviral agents. To further contribute to the development of new drugs against B19V, our research was focused on the synthesis, characterization and evaluation of antiviral activity of some new 3-(imidazo[2,1-

Indexed as

Antiviral AgentsBenzopyransCell ProliferationCells, CulturedCell SurvivalCoumarinsHumansMolecular StructureParvoviridae InfectionsParvovirus B19, HumanStructure-Activity RelationshipVirus ReplicationAntiviral AgentsBenzopyransCoumarinsantiviral activitycoumarinsimidazo[2,1-b]thiazoleparvovirus B19

Identifiers

PMID30875983
PMCPMC6470553

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.