Evidence map›Paper›PMID 30875968›Full record

ArticleAntibiotics (Basel, Switzerland)2019

A Molecular Modeling Approach to Identify Novel Inhibitors of the Major Facilitator Superfamily of Efflux Pump Transporters.

Sandra G Zárate, Paula Morales, Katarzyna Świderek, Victor M Bolanos-Garcia, Agatha Bastida

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. The Art of War withAntibiotics (Basel, Switzerland) · 2023
    Review
  4. Effect of Indole-Containing Pyrazino[2,1-Antibiotics (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Repurposing pantoprazole and haloperidol as efflux pump inhibitors in azole resistant clinicalSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Prevalence and Therapies of Antibiotic-Resistance inFrontiers in cellular and infection microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Sandra G ZárateFacultad de Tecnología, Carrera de Ingeniería Química, Universidad Mayor Real y Pontífice de San Francisco Xavier de Chuquisaca, Regimiento Campos 180, Casilla 60-B, Sucre, Bolivia. zarate.sandra@usfx.bo.ORCID 0000-0003-2501-388X
Paula MoralesInstituto de Química Física Rocasolano, c/Serrano 119, E-28006 Madrid, Spain. pmorales@iqfr.csic.es.ORCID 0000-0002-6209-8600
Katarzyna ŚwiderekDepartment de Química Física i Analítica, Universitat Jaume I, 12071 Castelló, Spain. swiderek@uji.es.ORCID 0000-0002-7528-1551
Victor M Bolanos-GarciaDepartment of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 OBP, UK. vbolanos-garcia@brookes.ac.uk.
Agatha BastidaDepartamento de Química Bio-orgánica, IQOG, c/ Juan de la Cierva 3, E-28006 Madrid, Spain. agatha.bastida@csic.es.
Instituto de Química Física Blas Cabrera · ESInstituto de Química Orgánica General · ESOxford Brookes University · GBUniversitat Jaume I · ESUniversity of Saint Francis Xavier · BO

Funding

Ministerio de Economía, Industria y Competitividad, Gobierno de España COOPB20237Ministerio de Economía, Industria y Competitividad, Gobierno de España CTQ2016-79255-PMinisterio de Economía, Industria y Competitividad, Gobierno de España IJCI-2016-27503
6 · The paper itself

Abstract

Multidrug efflux systems play a prominent role in medicine, as they are important contributors to bacterial antibiotic resistance. NorA is an efflux pump transporter from the major facilitator superfamily that expels numerous drug compounds across the inner membrane of

Indexed as

bioinformaticsmajor facilitator super familymolecular dockingNorA efflux pumpS. aureus

Identifiers

PMID30875968
PMCPMC6466568
OpenAlexW2921244157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.