Evidence map›Paper›PMID 30875939›Full record

ArticleMicroorganisms2019

Supercoil Levels in

Nikolay S Rovinskiy, Andrews A Agbleke, Olga N Chesnokova, N Patrick Higgins

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. AssessingbioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Structural basis of chiral wrap and T-segment capture byProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Frontiers in microbiology · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. DNA Supercoiling: an Ancestral Regulator of Gene Expression in Pathogenic Bacteria?Computational and structural biotechnology journal · 2019
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nikolay S RovinskiyDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294-0024, USA. nikolay.rovinskiy@aol.com.
Andrews A AgblekeDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294-0024, USA. agbleke@fas.harvard.edu.
Olga N ChesnokovaDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294-0024, USA. ochesnokov@fau.edu.
N Patrick HigginsDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294-0024, USA. nphiggin@uab.edu.ORCID 0000-0001-7884-7461
University of Alabama at Birmingham · US

Funding

National Institutes of Health GM33143
6 · The paper itself

Abstract

Prokaryotes have an essential gene-gyrase-that catalyzes negative supercoiling of plasmid and chromosomal DNA. Negative supercoils influence DNA replication, transcription, homologous recombination, site-specific recombination, genetic transposition and sister chromosome segregation. Although

Indexed as

DNA gyrase is an enzyme with two protein subunitsDNA topology is investigated that involves two types of DNA coilinggamma delta (γδ) resolvase is a site-specific recombinase from the γδ transposon the that utilizes (−) supercoils to delete a DNA sequence that is flanked by 100 bp Res sitesGyrA and GyrB that catalyzes (−) supercoiling at the expense of ATP hydrolysisgyrase processivity refers to the number of reaction cycles one enzyme carries out in a single DNA binding eventRNA polymerase (RNAP)the E. coli and Salmonella condensin is a multi-protein complex composed of three proteins, MukB, MukE, and MukF that compacts chromosomal DNAthe first type is right-handed coils that Watson/Crick DNA strands adopt by winding around each other every 10.6 base pairs, the second type involves coiling of the double strands around each other in either a left handed (−) or right handed (+) directionthe GyrA C-terminal domain (CTD) includes a long DNA binding section that has 6 pinwheel elements plus a short 35–38 amino acid terminus called the tailthe Q10 rule states that reaction rates double for every 10° C increase in temperature

Identifiers

PMID30875939
PMCPMC6463007
OpenAlexW2921056962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.