Evidence map›Paper›PMID 30875930›Full record

ArticleMolecules (Basel, Switzerland)2019

Chemical Characterization and DNA Fingerprinting of

Ivano Vigliante, Giuseppe Mannino, Massimo E Maffei

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07777328 (The Effect of 5-hydroxytryptophan on Microsaccades and Distractibility in Individual With High Levels of ADHD Traits), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07777328 narecruitingnot on this mapstarted 2025, after this paper: background citation

The Effect of 5-hydroxytryptophan on Microsaccades and Distractibility in Individual With High Levels of ADHD Traits: a Randomised, Double-blind Trial

TypeinterventionalSponsorUniversity of SheffieldRan2025 to 2027Enrolled150ConditionsAttention Deficit and Hyperactivity Disorder (ADHD), Attention Deficit Hyperactivity Disorder in Adults, Attention DeficitsArms5-hydroxytryptophan (food supplement) 200mg, 5-hydroxytryptophan (food supplement) 300mg, Placebo
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Serotonin dysfunction in ADHD.Journal of neurodevelopmental disorders · 2025
    Review
  3. Biological Activity and Metabolomics ofAntioxidants (Basel, Switzerland) · 2023
    Article
  4. Discrimination of Green Coffee (Antioxidants (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Review
  7. Review
  8. Changes in the Phytochemical Profile and Antioxidant Properties ofInternational journal of molecular sciences · 2022
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Chemical Profile and Biological Activity of Cherimoya (Molecules (Basel, Switzerland) · 2020
    Article
  20. Nutrients · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ivano VigliantePlant Physiology Unit, Department of Life Sciences and Systems Biology, University of Turin, Via Quarello 15/a, 10135 Turin, Italy. ivano.vigliante@unito.it.
Giuseppe ManninoPlant Physiology Unit, Department of Life Sciences and Systems Biology, University of Turin, Via Quarello 15/a, 10135 Turin, Italy. giuseppe.mannino@unito.it.
Massimo E MaffeiPlant Physiology Unit, Department of Life Sciences and Systems Biology, University of Turin, Via Quarello 15/a, 10135 Turin, Italy. massimo.maffei@unito.it.ORCID 0000-0001-6814-2353
University of Turin · IT

Funding

Università degli Studi di Torino Local grants
6 · The paper itself

Abstract

background

methodsIn order to characterize the chemical components of

results5-HTP was the most representative compound, followed by lower percentages of the β-carboline alkaloid derivative griffonine and other alkaloids. Fatty acids were dominated by the unsaturated fatty acids linoleic acid and oleic acid, followed by the saturated fatty acids stearic and palmitic acids. PCR analysis of the internal transcribed spacer amplified sequence showed a major band at about 758 bp, whereas the PCR⁻RFLP analysis of this sequence using three different restriction enzymes (

conclusionsThe combined chemical and molecular analysis of

Indexed as

5-HydroxytryptophanCarbolinesDNA FingerprintingFatty AcidsGriffoniaMedicine, TraditionalMolecular StructurePlant ExtractsPolymorphism, Restriction Fragment LengthSeedsSequence Analysis, DNA5-HydroxytryptophanCarbolinesFatty AcidsnorharmanPlant Extracts5-hydroxy-l-tryptophan (5-HTP)CaesalpiniaceaeDNA fingerprintingfatty acidsGriffonia simplicifoliainternal transcribed spacer (ITS)PCR–RFLP

Identifiers

PMID30875930
PMCPMC6472197
OpenAlexW2921039011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.