Evidence map›Paper›PMID 30875791›Full record

ArticleInternational journal of molecular sciences2019

A Smart Imaging Workflow for Organ-Specific Screening in a Cystic Kidney Zebrafish Disease Model.

Gunjan Pandey, Jens H Westhoff, Franz Schaefer, Jochen Gehrig

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Renal Ciliopathies: Sorting Out Therapeutic Approaches for Nephronophthisis.Frontiers in cell and developmental biology · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. Frontiers in cell and developmental biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gunjan PandeyAcquifer is a division of Ditabis, Digital Biomedical Imaging Systems AG, 75179 Pforzheim, Germany. gunjan.pandey@med.uni-heidelberg.de.
Jens H WesthoffDepartment of Pediatrics I, University Children's Hospital Heidelberg, 69120 Heidelberg, Germany. jens.westhoff@med.uni-heidelberg.de.
Franz SchaeferDepartment of Pediatrics I, University Children's Hospital Heidelberg, 69120 Heidelberg, Germany. franz.schaefer@med.uni-heidelberg.de.ORCID 0000-0001-7564-9937
Jochen GehrigAcquifer is a division of Ditabis, Digital Biomedical Imaging Systems AG, 75179 Pforzheim, Germany. j.gehrig@acquifer.de.
Heidelberg University · DE

Funding

H2020 Marie Skłodowska-Curie Actions RENALTRACT ITN project N ° 642937
6 · The paper itself

Abstract

The zebrafish is being increasingly used in biomedical research and drug discovery to conduct large-scale compound screening. However, there is a lack of accessible methodologies to enable automated imaging and scoring of tissue-specific phenotypes at enhanced resolution. Here, we present the development of an automated imaging pipeline to identify chemical modifiers of glomerular cyst formation in a zebrafish model for human cystic kidney disease. Morpholino-mediated knockdown of intraflagellar transport protein Ift17

Indexed as

Adaptor Proteins, Signal TransducingAlgorithmsAnimalsCarrier ProteinsCytoskeletal ProteinsDisease Models, AnimalEmbryo, NonmammalianGene Knockdown TechniquesHumansImage Processing, Computer-AssistedKidneyOrgan SpecificityPhenotypePolycystic Kidney DiseasesSmall Molecule LibrariesSoftwareAdaptor Proteins, Signal TransducingCarrier ProteinsCytoskeletal ProteinsIFT172 protein, humanSmall Molecule Librariesautomated imaginghigh-content screeningimage analysiszebrafish

Identifiers

PMID30875791
PMCPMC6471943
OpenAlexW2922262151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.