ArticleViruses2019
Enhanced Autophagy Contributes to Reduced Viral Infection in Black Flying Fox Cells.
Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- Disease tolerance as immune defense strategy in bats: One size fits all?PLoS pathogens · 2024Review
- A tale of endurance: bats, viruses and immune dynamics.Future microbiology · 2024Review
- The relationships amongInternational journal for parasitology. Parasites and wildlife · 2024Article
- Reservoir host immunology and life history shape virulence evolution in zoonotic viruses.PLoS biology · 2023Article
- Bats host the most virulent-but not the most dangerous-zoonotic viruses.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Autophagy Modulators in Coronavirus Diseases: A Double Strike in Viral Burden and Inflammation.Frontiers in cellular and infection microbiology · 2022Review
- ReprogrammedMicroorganisms · 2021Article
- Disease Tolerance during Viral-Bacterial Co-Infections.Viruses · 2021Review
- Revelations About Aging and Disease from Unconventional Vertebrate Model Organisms.Annual review of genetics · 2021Review
- Evolution of mammalian longevity: age-related increase in autophagy in bats compared to other mammals.Aging · 2021Article
- Article
- Asymptomatic SARS-CoV-2 infection: is it all about being refractile to innate immune sensing of viral spare-parts?-Clues from exotic animal reservoirs.Pathogens and disease · 2021Article
- Review
- Alternative Animal Models of Aging Research.Frontiers in molecular biosciences · 2021Review
- The World Goes Bats: Living Longer and Tolerating Viruses.Cell metabolism · 2020Review
- Emerging New Concepts of Degrader Technologies.Trends in pharmacological sciences · 2020Review
- Establishment of a longitudinal pre-clinical model of lyssavirus infection.Journal of virological methods · 2020Article
- SARS-CoV-2 and Bats: From Flight to Fighting COVID-19.JACC. Basic to translational science · 2020Article
- Egyptian Rousette IFN-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Bats are increasingly implicated as hosts of highly pathogenic viruses. The underlying virus⁻host interactions and cellular mechanisms that promote co-existence remain ill-defined, but physiological traits such as flight and longevity are proposed to drive these adaptations. Autophagy is a cellular homeostatic process that regulates ageing, metabolism, and intrinsic immune defense. We quantified basal and stimulated autophagic responses in black flying fox cells, and demonstrated that although black flying fox cells are susceptible to Australian bat lyssavirus (ABLV) infection, viral replication is dampened in these bat cells. Black flying fox cells tolerated prolonged ABLV infection with less cell death relative to comparable human cells, suggesting post-entry mechanisms interference with virus replication. An elevated basal autophagic level was observed and autophagy was induced in response to high virus doses. Pharmacological stimulation of the autophagy pathway reduced virus replication, indicating autophagy acts as an anti-viral mechanism. Enhancement of basal and virus-induced autophagy in bat cells connects related reports that long-lived species possess homeostatic processes that dampen oxidative stress and macromolecule damage. Exemplifying the potential that evolved cellular homeostatic adaptations like autophagy may secondarily act as anti-viral mechanisms, enabling bats to serve as natural hosts to an assortment of pathogenic viruses. Furthermore, our data suggest autophagy-inducing drugs may provide a novel therapeutic strategy for combating lyssavirus infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.