ArticleAngewandte Chemie (International ed. in English)2019
A Simple Approach to Design Proteins for the Sustainable Synthesis of Metal Nanoclusters.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Engineered protein nanoclusters reduce liver fibrosis and hepatocellular carcinoma in mice models.Bioactive materials · 2026Article
- Engineered Plasmonic and Fluorescent Nanomaterials for Biosensing, Motion, Imaging, and Therapeutic Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Synthesis of Greenish-Yellow Fluorescent Copper Nanocluster for the Selective and Sensitive Detection of Fipronil Pesticide in Vegetables and Grain Samples.Journal of fluorescence · 2024Article
- Chaperone/Polymer Complexation of Protein-Based Fluorescent Nanoclusters against Silica Encapsulation-Induced Physicochemical Stresses.Biomacromolecules · 2024Article
- Size and charge effects of metal nanoclusters on antibacterial mechanisms.Journal of nanobiotechnology · 2023Review
- Potential impact of various surface ligands on the cellular uptake and biodistribution characteristics of red, green, and blue emitting Cu nanoclusters.RSC advances · 2023Article
- Protein-Templated Metal Nanoclusters: Molecular-like Hybrids for Biosensing, Diagnostics and Pharmaceutics.Molecules (Basel, Switzerland) · 2023Review
- Luminescent Gold Nanoclusters for Bioimaging: Increasing the Ligand Complexity.Nanomaterials (Basel, Switzerland) · 2023Review
- Engineered Protein-Driven Synthesis of Tunable Iron Oxide Nanoparticles as T1 and T2 Magnetic Resonance Imaging Contrast Agents.Chemistry of materials : a publication of the American Chemical Society · 2022Article
- Fabrication of avidin-stabilized gold nanoclusters with dual emissions and their application in biosensing.Journal of nanobiotechnology · 2022Article
- Metal-Organic Enzyme Nanogels as Nanointegrated Self-Reporting Chemobiosensors.ACS applied materials & interfaces · 2022Article
- Photoluminescent nanocluster-based probes for bioimaging applications.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022Review
- Correlative 3D cryo X-ray imaging reveals intracellular location and effect of designed antifibrotic protein-nanomaterial hybrids.Chemical science · 2021Article
- Engineered Repeat Protein Hybrids: The New Horizon for Biologic Medicines and Diagnostic Tools.Accounts of chemical research · 2021Article
- Development of a Hybrid Bioinorganic Nanobiocatalyst: Remarkable Impact of the Immobilization Conditions on Activity and Stability of β-Galactosidase.Molecules (Basel, Switzerland) · 2021Article
- Rapid synthesis of fluorescent bovine serum albumin-gold nanoclusters complex for glutathione determination.Mikrochimica acta · 2021Article
- Synergistic integration of metal nanoclusters and biomolecules as hybrid systems for therapeutic applications.Acta pharmaceutica Sinica. B · 2021Review
- Biomarker sensing platforms based on fluorescent metal nanoclusters.Nanoscale advances · 2021Review
- Nanotheranostic Application of Fluorescent Protein-Gold Nanocluster Hybrid Materials: A Mini-review.Nanotheranostics · 2021Review
- Engineering multifunctional metal/protein hybrid nanomaterials as tools for therapeutic intervention and high-sensitivity detection.Chemical science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Metal nanoclusters (NCs) are considered ideal nanomaterials for biological applications owing to their strong photoluminescence (PL), excellent photostability, and good biocompatibility. This study presents a simple and versatile strategy to design proteins, via incorporation of a di-histidine cluster coordination site, for the sustainable synthesis and stabilization of metal NCs with different metal composition. The resulting protein-stabilized metal NCs (Prot-NCs) of gold, silver, and copper are highly photoluminescent and photostable, have a long shelf life, and are stable under physiological conditions. The biocompatibility of the clusters was demonstrated in cell cultures in which Prot-NCs showed efficient cell internalization without affecting cell viability or losing luminescence. Moreover, the approach is translatable to other proteins to obtain Prot-NCs for various biomedical applications such as cell imaging or labeling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.