ArticlePLoS genetics2019
The molecular and cellular basis of olfactory response to tsetse fly attractants.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
- Molecular bases of insect odorant receptor function: specificity and evolution.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Receptor sequence divergence, gain, loss, duplication, and neofunctionalization drive olfactory adaptation inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Expanding the sensory horizon: chemosensory receptors beyond traditional olfactory and taste organs in insects.Science China. Life sciences · 2026Review
- Identification of two odorant receptors tuned to alarm pheromone compounds in the honey bee Apis mellifera.Communications biology · 2025Article
- Genomic plasticity drives olfactory adaptation in a pest fly.bioRxiv : the preprint server for biology · 2025Article
- Article
- Host Plant Odour and Sex Pheromone are Integral to Mate Finding in Codling Moth.Journal of chemical ecology · 2025Article
- Combining Machine Learning and Electrophysiology for Insect Odorant Receptor Studies.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Accelerating Ligand Discovery for Insect Odorant Receptors.International journal of biological sciences · 2025Article
- Chromosome-level genome assembly of Phortica okadai, a vector of Thelazia callipaeda.Scientific data · 2024Article
- Article
- Targeted deletion of olfactory receptors inJournal of neurogenetics · 2024Article
- Antennal Transcriptome Screening and Identification of Chemosensory Proteins in the Double-Spine European Spruce Bark Beetle,International journal of molecular sciences · 2024Article
- Structural basis of odor sensing by insect heteromeric odorant receptors.Science (New York, N.Y.) · 2024Article
- Antenna-Biased Odorant Receptor PstrOR17 Mediates Attraction ofInternational journal of molecular sciences · 2024Article
- Exitron splicing of odor receptor genes inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- A light in the dark: a mid-Cretaceous bioluminescent firefly with specialized antennal sensory organs.Proceedings. Biological sciences · 2024Article
- Pathogen-Mediated Alterations of Insect Chemical Communication: From Pheromones to Behavior.Pathogens (Basel, Switzerland) · 2023Review
- A volatile sex attractant of tsetse flies.Science (New York, N.Y.) · 2023Article
- Heterologous investigation of metabotropic and ionotropic odorant receptors in ab3A neurons ofFrontiers in molecular biosciences · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Dipteran or "true" flies occupy nearly every terrestrial habitat, and have evolved to feed upon a wide variety of sources including fruit, pollen, decomposing animal matter, and even vertebrate blood. Here we analyze the molecular, genetic and cellular basis of odor response in the tsetse fly Glossina morsitans, which feeds on the blood of humans and their livestock, and is a vector of deadly trypanosomes. The G. morsitans antenna contains specialized subtypes of sensilla, some of which line a sensory pit not found in the fruit fly Drosophila. We characterize distinct patterns of G. morsitans Odor receptor (GmmOr) gene expression in the antenna. We devise a new version of the "empty neuron" heterologous expression system, and use it to functionally express several GmmOrs in a mutant olfactory receptor neuron (ORN) of Drosophila. GmmOr35 responds to 1-hexen-3-ol, an odorant found in human emanations, and also alpha-pinene, a compound produced by malarial parasites. Another receptor, GmmOr9, which is expressed in the sensory pit, responds to acetone, 2-butanone and 2-propanol. We confirm by electrophysiological recording that neurons of the sensory pit respond to these odorants. Acetone and 2-butanone are strong attractants long used in the field to trap tsetse. We find that 2-propanol is also an attractant for both G. morsitans and the related species G. fuscipes, a major vector of African sleeping sickness. The results identify 2-propanol as a candidate for an environmentally friendly and practical tsetse attractant. Taken together, this work characterizes the olfactory system of a highly distinct kind of fly, and it provides an approach to identifying new agents for controlling the fly and the devastating diseases that it carries.
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