Evidence map›Paper›PMID 30875259›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2019

Conduction in the right and left ventricle is differentially regulated by protein kinases and phosphatases: implications for arrhythmogenesis.

Alexey V Zaitsev, Natalia S Torres, Keiko M Cawley, Amira D Sabry, Junco S Warren, Mark Warren

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  4. Article
  5. Stop the beat to see the rhythm: excitation-contraction uncoupling in cardiac research.American journal of physiology. Heart and circulatory physiology · 2021
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alexey V ZaitsevNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, Utah.
Natalia S TorresNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, Utah.
Keiko M CawleyNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, Utah.
Amira D SabryNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, Utah.
Junco S WarrenNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, Utah.ORCID 0000-0001-5231-4181
Mark WarrenNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, Utah.
University of Utah · US

Funding

His-Purkinje Pacing for Low Energy Implantable Cardioverter DefibrillatorsR01HL128752 · NHLBI · UNIVERSITY OF UTAH · PI DOSDALL, DEREK J · 2015 to 2024
$5.0M
Physiology and Biophysics of Cardiac Slo2.1 ChannelsR01HL103877 · NHLBI · UNIVERSITY OF UTAH · PI SANGUINETTI, MICHAEL CRAIG, ZAITSEV, ALEXEY V · 2011 to 2015
$2.1M
NHLBI NIH HHS R01 HL103877NHLBI NIH HHS R01 HL128752
6 · The paper itself

Abstract

The "stress" kinases cAMP-dependent protein kinase (PKA) and calcium/calmodulin-dependent protein kinase II (CaMKII), phosphorylate the Na

Indexed as

Heart RateVentricular Function, LeftAction PotentialsAnimalsArrhythmias, CardiacCalcium-Calmodulin-Dependent Protein Kinase Type 2Cardiac Pacing, ArtificialCyclic AMP-Dependent Protein KinasesDisease Models, AnimalEnzyme InhibitorsFemaleHeart VentriclesIsolated Heart PreparationMalePhosphoprotein PhosphatasesRabbitsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP-Dependent Protein KinasesEnzyme InhibitorsPhosphoprotein PhosphatasesCaMKIIconduction and arrhythmiaphosphatasesPKAright ventricle outflow tract

Identifiers

PMID30875259
PMCPMC6620685
OpenAlexW2922473142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.