ReviewAnnals of the New York Academy of Sciences2019
Neural mechanisms of social homeostasis.
Review in Annals of the New York Academy of Sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
117 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Coordination of social behaviors by the bed nucleus of the stria terminalis.The European journal of neuroscience · 2022Pooled it
- Preliminary evidence that oxytocin does not improve mentalizing in women with schizophrenia.Hormones and behavior · 2021Trial
- Peripheral Inflammation and Sleep Loss Induce Coordinated Motivational Changes: An Experimental Two-Hit Stress Model.Journal of sleep research · 2026Article
- Social Physiology: Human homeostasis is more efficient in social proximity.Science advances · 2026Article
- Age and loneliness relate to reduced trust learning and alterations in amygdala function.iScience · 2026Article
- Contextualizing the adolescent social brain: Links to social health using data from the Adolescent Brain Cognitive Development Study.Developmental cognitive neuroscience · 2026Article
- Partner separation and sex contribute to anxiety-like behavior, but partner separation alone amplifies hippocampal inflammation following immune challenge.Brain, behavior, and immunity · 2026Article
- Review
- Oxytocin Modulation of Spinal Circuits Drives Therapeutic Benefits of Massage.bioRxiv : the preprint server for biology · 2026Article
- Factors Modulating the Effects of Juvenile Social Isolation on Adult Social Behavior in Rodents.Developmental psychobiology · 2026Review
- Neural Mechanisms of Social Homeostasis: Dynamic Range Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Neural Bases of Collective Social Behavior and Group Interactions across Species.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- SNAP-47 mediates somatic oxytocin dynamics in hypothalamic neurons.Communications biology · 2026Article
- Sensory Deprivation and the Brain: Neurobiological Mechanisms, Psychological Effects, and Clinical Implications.Brain sciences · 2026Review
- Asymmetric loneliness response to social connectedness around individual set points.Scientific reports · 2026Article
- Companion animals support human wellbeing and health: evolutionary, behavioral and physiological contexts.Frontiers in psychology · 2026Review
- An idiographic network approach to modeling daily loneliness and paranoia in psychosis: implications for personalized interventions.Frontiers in psychiatry · 2026Article
- Association between loneliness and hippocampal responses to dynamic social stimuli in psychotic disorders.Psychological medicine · 2025Article
- The temporal relationships between social motivation and social interactions in people with serious mental illness and recent homelessness.Journal of mental health (Abingdon, England) · 2025Article
- A striosomal accumbens pathway drives stereotyped behavior through an aversive Esr1+ hypothalamic-habenula circuit.Science advances · 2025Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Social connections are vital to survival throughout the animal kingdom and are dynamic across the life span. There are debilitating consequences of social isolation and loneliness, and social support is increasingly a primary consideration in health care, disease prevention, and recovery. Considering social connection as an "innate need," it is hypothesized that evolutionarily conserved neural systems underlie the maintenance of social connections: alerting the individual to their absence and coordinating effector mechanisms to restore social contact. This is reminiscent of a homeostatic system designed to maintain social connection. Here, we explore the identity of neural systems regulating "social homeostasis." We review findings from rodent studies evaluating the rapid response to social deficit (in the form of acute social isolation) and propose that parallel, overlapping circuits are engaged to adapt to the vulnerabilities of isolation and restore social connection. By considering the neural systems regulating other homeostatic needs, such as energy and fluid balance, we discuss the potential attributes of social homeostatic circuitry. We reason that uncovering the identity of these circuits/mechanisms will facilitate our understanding of how loneliness perpetuates long-term disease states, which we speculate may result from sustained recruitment of social homeostatic circuits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.