Evidence map›Paper›PMID 30875021›Full record

ArticleNeurology and therapy2019

An Overview of High-Efficacy Drugs for Multiple Sclerosis: Gulf Region Expert Opinion.

Raed Alroughani, Jihad Said Inshasi, Dirk Deleu, Jasem Al-Hashel, Mustafa Shakra, Osama Robin Elalamy, Ahmed Osman Shatila, Abdullah Al-Asmi, Isa Al Sharoqi, Beatriz Garcia Canibano and 1 more

Abstract read
In one paragraph

Article in Neurology and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Raed AlroughaniDivision of Neurology, Department of Medicine, Amiri Hospital, Sharq, Kuwait. alroughani@gmail.com.
Jihad Said InshasiNeurology, Rashid Hospital, DMC, DHA, Dubai, UAE.
Dirk DeleuDepartment of Neurology, Hamad Medical Corporation, Doha, Qatar.
Jasem Al-HashelDepartment of Neurology, Ibn Sina Hospital, Kuwait City, Kuwait.
Mustafa ShakraDepartment of Neurology, Sheikh Khalifa Medical City, Abu Dhabi, UAE.
Osama Robin ElalamyHamad Medical Corporation, Weill Cornell Medical College, Ar Rayyān, Qatar.
Ahmed Osman ShatilaAl Mafraq Hospital, Abu Dhabi, UAE.
Abdullah Al-AsmiDepartment of Medicine, SQUH, Seeb, Sultanate of Oman.
Isa Al SharoqiSalmaniya Medical Complex, Manama, Bahrain.
Beatriz Garcia CanibanoHamad Medical Corporation, Doha, Qatar.
Amir BoshraMerck Serono Middle East FZ LTD, Dubai, UAE.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article discusses the opinions of the multiple sclerosis (MS) experts in the Gulf region on the use of high-efficacy disease-modifying drugs (DMDs; natalizumab, fingolimod, alemtuzumab, cladribine tablets, and ocrelizumab) in clinical practice. The experts reviewed the current literature including pivotal clinical trials and meta-analyses for high-efficacy DMDs, supplemented by the expert opinions on the usage of these DMDs in clinical practice. Several criteria were discussed by the panel based on different efficacy, safety, and convenience attributes. The panel concluded that all the DMDs available for the treatment of MS have benefits and risks, which should be considered while discussing the treatment plan with the patient. It is important to have a personalized approach based on the risk-benefit assessment for each case. Common considerations while choosing treatments include effectiveness, side effects/safety, and convenience/route of administration.Funding: Merck Serono Middle East FZ LTD.

Indexed as

Disease-modifying drugsExpert opinionGulf regionMultiple sclerosisNeuroimmunology

Identifiers

PMID30875021
PMCPMC6534637

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.