Evidence map›Paper›PMID 30874987›Full record

ArticleDigestive diseases and sciences2019

Functional Role of Basolateral ClC-2 Channels in the Regulation of Duodenal Anion Secretion in Mice.

Chao Du, Jingjing Liu, Hanxing Wan, Hui Dong, Xiaoyan Zhao

Abstract read
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Intestinal secretory mechanisms and diarrhea.American journal of physiology. Gastrointestinal and liver physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Chao DuDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.ORCID 0000-0002-9336-8116
Jingjing LiuDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Hanxing WanDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Hui DongDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. h_uidong@163.com.
Xiaoyan ZhaoDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. zhaoxx@medmail.com.cn.
Army Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough ClC-2 channels are important in colonic Cl

methodsDuodenal mucosae from mice were stripped of seromuscular layers and mounted in Ussing chambers. Both duodenal short-circuit current (I

resultsLubiprostone, a selective ClC-2 activator, concentration-dependently increased both duodenal I

conclusionsWe have provided the first evidence for the novel functional role of basolateral ClC-2 channels in the regulation of duodenal anion secretion.

Indexed as

AnimalsChloride Channel AgonistsChloride ChannelsCLC-2 Chloride ChannelsCystic Fibrosis Transmembrane Conductance RegulatorDuodenumIntestinal MucosaLubiprostoneMiceMice, KnockoutCftr protein, mouseChloride Channel AgonistsChloride ChannelsCLC-2 Chloride ChannelsCystic Fibrosis Transmembrane Conductance RegulatorLubiprostoneBicarbonate secretionCFTRClC-2Duodenal

Identifiers

PMID30874987
OpenAlexW2921166740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.