Evidence map›Paper›PMID 30874873›Full record

ArticleRheumatology international2019

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio as predictors of 12-week treatment response and drug persistence of anti-tumor necrosis factor-α agents in patients with rheumatoid arthritis: a retrospective chart review analysis.

Han-Na Lee, Yun-Kyung Kim, Geun-Tae Kim, Eunyoung Ahn, Min Wook So, Dong Hyun Sohn, Seung-Geun Lee

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Article in Rheumatology international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Han-Na LeeDivision of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, 179 Gudeok-Ro, Seo-Gu, Busan, 49241, South Korea.
Yun-Kyung KimDivision of Rheumatology, Department of Internal Medicine, Kosin, University College of Medicine, Busan, South Korea.
Geun-Tae KimDivision of Rheumatology, Department of Internal Medicine, Kosin, University College of Medicine, Busan, South Korea.
Eunyoung AhnDivision of Rheumatology, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, South Korea.
Min Wook SoDivision of Rheumatology, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, South Korea.
Dong Hyun SohnDepartment of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, South Korea.
Seung-Geun LeeDivision of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, 179 Gudeok-Ro, Seo-Gu, Busan, 49241, South Korea. sglee@pusan.ac.kr.ORCID 0000-0002-5205-3978

Funding

Pusan National University Hospital This work was supported by a clinical research grant from Pusan National University Hospital in 2019
6 · The paper itself

Abstract

Data are scarce regarding the association of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with treatment response and persistence of anti-TNF-α agents in patients with rheumatoid arthritis (RA). Thus, we investigated whether baseline NLR and PLR could predict 12-week treatment response and long-term persistence of anti-TNF-α agents in RA patients. This is a retrospective chart review analysis of 82 women with RA who started anti-TNF-α agents as the first-line biologic therapy and 328 healthy age-matched women. RA patients were divided into high and low baseline NLR or PLR subgroups using the median split. European League against Rheumatism (EULAR) treatment response was evaluated at 12 weeks. RA patients had significantly higher NLR and PLR than controls. High baseline NLR and PLR groups showed higher 12-week EULAR non-response rate than low NLR (30% vs 7.1%, p = 0.01) and PLR groups (27.5% vs 9.5%, p = 0.047), respectively. After adjusting for confounding factors, high baseline NLR (OR 5.57, p = 0.014) and PLR (OR 4.24, p = 0.04) were significantly associated with a higher risk of EULAR non-response at 12 weeks. During the study period, 47 (57.3%) RA patients (lack of efficacy: n = 31; adverse events: n = 16) discontinued anti-TNF-α agents. High baseline NLR was associated with an increased risk of anti-TNF-α agent withdrawal due to lack of efficacy (HR 2.12, p = 0.045). Our data suggest that baseline NLR and PLR are useful markers for predicting the treatment outcome of anti-TNF-α agents in RA patients.

Indexed as

Lymphocyte CountMedication AdherenceNeutrophilsPlatelet CountAdultArthritis, RheumatoidCase-Control StudiesFemaleHumansLeukocyte CountMiddle AgedPrognosisRetrospective StudiesTreatment OutcomeTumor Necrosis Factor InhibitorsTumor Necrosis Factor InhibitorsBiomarkersBlood cellsRheumatoid arthritisTreatment outcomeTumor necrosis factor-alpha

Identifiers

PMID30874873

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.