Evidence map›Paper›PMID 30874628›Full record

ArticleCellular & molecular immunology2020

Liver-resident NK cells suppress autoimmune cholangitis and limit the proliferation of CD4

Zhi-Bin Zhao, Fang-Ting Lu, Hong-Di Ma, Yin-Hu Wang, Wei Yang, Jie Long, Qi Miao, Weici Zhang, Zhigang Tian, William M Ridgway and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. The Role of Inflammation in Cholestatic Liver Injury.Journal of inflammation research · 2023
    Review
  11. Article
  12. Single-Cell Characterization of Hepatic CD8Frontiers in immunology · 2022
    Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Animal Models of Autoimmune Liver Diseases: a Comprehensive Review.Clinical reviews in allergy & immunology · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Zhi-Bin Zhao *Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510180, China.
Fang-Ting Lu *Center for Reproductive Medicine, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China.
Hong-Di Ma *Institute of Immunology and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Yin-Hu WangInstitute of Immunology and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Wei YangInstitute of Immunology and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Jie LongDepartment of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510180, China.
Qi MiaoDepartment of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Weici ZhangDivision of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA, USA.
Zhigang TianInstitute of Immunology and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, China.
William M RidgwayDivision of Immunology, Allergy and Rheumatology, University of Cincinnati, Cincinnati, OH, 45267, USA.
Jie CaoDepartment of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510180, China. eycaojie@scut.edu.cn.
M Eric GershwinDivision of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA, USA. megershwin@ucdavis.edu.
Zhe-Xiong LianDepartment of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510180, China. zxlian@scut.edu.cn.
University of Science and Technology of China · CNGuangzhou First People's Hospital · CNUniversity of California, Davis · USAnhui Provincial Hospital · CNShanghai Jiao Tong University · CNSouth China University of Technology · CNUniversity of Cincinnati · US

Funding

dnTGF Beta RII Mice and PBCR01DK090019 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GERSHWIN, MERRILL E, RIDGWAY, WILLIAM M · 2010 to 2017
$3.8M
NIDDK NIH HHS R01 DK090019
6 · The paper itself

Abstract

Liver-resident NK cells are distinct from conventional NK cells and play an important role in the maintenance of liver homeostasis. How liver-resident NK cells participate in autoimmune cholangitis remains unclear. Here, we extensively investigated the impact of NK cells in the pathogenesis of autoimmune cholangitis utilizing the well-established dnTGFβRII cholangitis model, NK cell-deficient (Nfil3

Indexed as

Adoptive TransferAnimalsAutoimmune DiseasesBasic-Leucine Zipper Transcription FactorsB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytokinesDisease Models, AnimalDisease ProgressionFemaleHybridomasKiller Cells, NaturalLiverLiver Cirrhosis, BiliaryMaleBasic-Leucine Zipper Transcription FactorsCytokinesNfil3 protein, mouseReceptor, Transforming Growth Factor-beta Type IITgfbr2 protein, mouseCD4+ T cellCholangitisLiver-resident NKSuppression

Identifiers

PMID30874628
PMCPMC7000693
OpenAlexW2921495074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.