ArticleScientific reports2019
Copper transporter COPT5 participates in the crosstalk between vacuolar copper and iron pools mobilisation.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- They look like gold: CITF1 and FIT interaction mediate cross-talk between iron and copper.The Plant cell · 2026Article
- Age-dependent differential iron deficiency responses of rosette leaves during reproductive stages in Arabidopsis thaliana.Journal of experimental botany · 2025Article
- Barriers and carriers for transition metal homeostasis in plants.Plant communications · 2025Review
- Copper connections: coordinating transport, sensing and systemic signalling in plants.Quantitative plant biology · 2025Review
- Review
- Physiological and Molecular Mechanisms of Plant Responses to Copper Stress.International journal of molecular sciences · 2022Review
- Natural Molecular Mechanisms of Plant Hyperaccumulation and Hypertolerance towards Heavy Metals.International journal of molecular sciences · 2022Review
- Advantages and limits to copper phytoextraction in vineyards.Environmental science and pollution research international · 2022Review
- Age Dependent Partitioning Patterns of Essential Nutrients Induced by Copper Feeding Status in Leaves and Stems of Poplar.Frontiers in plant science · 2022Article
- Involvement of Arabidopsis Multi-Copper Oxidase-EncodingFrontiers in plant science · 2021Article
- The Geomagnetic Field Is a Contributing Factor for an Efficient Iron Uptake inFrontiers in plant science · 2020Article
- Characterization of the Copper Transporters fromInternational journal of molecular sciences · 2019Article
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5 authors.
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Abstract
Copper (Cu) deficiency affects iron (Fe) homeostasis in several plant processes, including the increased Fe requirements due to cuproprotein substitutions for the corresponding Fe counterpart. Loss-of-function mutants from Arabidopsis thaliana high affinity copper transporter COPT5 and Fe transporters NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 3/4 (NRAMP3 and NRAMP4) were used to study the interaction between metals internal pools. A physiological characterisation showed that the copt5 mutant is sensitive to Fe deficiency, and that nramp3nramp4 mutant growth was severely affected under limiting Cu. By a transcriptomic analysis, we observed that NRAMP4 expression was highly induced in the copt5 mutant under Cu deficiency, while COPT5 was overexpressed in the nramp3nramp4 mutant. As a result, an enhanced mobilisation of the vacuolar Cu or Fe pools, when the other metal export through the tonoplast is impaired in the mutants, has been postulated. However, metals coming from internal pools are not used to accomplish the increased requirements that derive from metalloprotein substitution under metal deficiencies. Instead, the metal concentrations present in aerial parts of the copt5 and nramp3nramp4 mutants conversely show compensated levels of these two metals. Together, our data uncover an interconnection between Cu and Fe vacuolar pools, whose aim is to fulfil interorgan metal translocation.
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