ArticleScientific reports2019
Probing hair cell's mechano-transduction using two-tone suppression measurements.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Outer hair cells stir cochlear fluids.eLife · 2025Article
- Corti Fluid Is a Medium for Outer Hair Cell Force Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Outer hair cells stir cochlear fluids.bioRxiv : the preprint server for biology · 2024Article
- Rate-dependent cochlear outer hair cell force generation: Models and parameter estimation.Biophysical journal · 2024Article
- Intracochlear overdrive: Characterizing nonlinear wave amplification in the mouse apex.The Journal of the Acoustical Society of America · 2023Article
- Deiters Cells Act as Mechanical Equalizers for Outer Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Complex dynamics of hair bundle of auditory nervous system (I): spontaneous oscillations and two cases of steady states.Cognitive neurodynamics · 2022Article
- The Elusive Cochlear Filter: Wave Origin of Cochlear Cross-Frequency Masking.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Model of cochlear microphonic explores the tuning and magnitude of hair cell transduction current.Biophysical journal · 2021Article
- Utricular Sensitivity during Hydrodynamic Displacements of the Macula.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- Interactions between Passive and Active Vibrations in the Organ of Corti In Vitro.Biophysical journal · 2020Article
- Nonlinear cochlear mechanics without direct vibration-amplification feedback.Physical review researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
When two sound tones are delivered to the cochlea simultaneously, they interact with each other in a suppressive way, a phenomenon referred to as two-tone suppression (2TS). This nonlinear response is ascribed to the saturation of the outer hair cell's mechano-transduction. Thus, 2TS can be used as a non-invasive probe to investigate the fundamental properties of cochlear mechano-transduction. We developed a nonlinear cochlear model in the time domain to interpret 2TS data. The multi-scale model incorporates cochlear fluid dynamics, organ of Corti (OoC) mechanics and outer hair cell electrophysiology. The model simulations of 2TS show that the threshold amplitudes and rates of low-side suppression are dependent on mechano-transduction properties. By comparing model responses to existing 2TS measurement data, we estimate intrinsic characteristics of mechano-transduction such as sensitivity and adaptation. For mechano-transduction sensitivity at the basal location (characteristic frequency of 17 kHz) at 0.06 nm
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.