Evidence map›Paper›PMID 30874573›Full record

ArticleScientific reports2019

Memantine prodrug as a new agent for Alzheimer's Disease.

Simona Sestito, Simona Daniele, Deborah Pietrobono, Valentina Citi, Lorenza Bellusci, Grazia Chiellini, Vincenzo Calderone, Claudia Martini, Simona Rapposelli

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 81 citations in OpenAlex.

  1. Review
  2. Thiourea-Based HAntioxidants (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Hydrogen Sulfide Signaling in Neurodegenerative Movement Disorders.Handbook of experimental pharmacology · 2026
    Review
  7. Review
  8. Black gas, bright future: HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  9. Intersection of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Pills of Multi-Target HInternational journal of molecular sciences · 2024
    Review
  17. Review
  18. Plants and Mushrooms as Possible New Sources of HInternational journal of molecular sciences · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Simona SestitoDepartment of Pharmacy, University of Pisa, Pisa, 56126, Italy.
Simona DanieleDepartment of Pharmacy, University of Pisa, Pisa, 56126, Italy.
Deborah PietrobonoDepartment of Pharmacy, University of Pisa, Pisa, 56126, Italy.
Valentina CitiDepartment of Pharmacy, University of Pisa, Pisa, 56126, Italy.
Lorenza BellusciDepartment of Pathology, University of Pisa, Pisa, 56126, Italy.
Grazia ChielliniDepartment of Pathology, University of Pisa, Pisa, 56126, Italy.
Vincenzo CalderoneDepartment of Pharmacy, University of Pisa, Pisa, 56126, Italy.
Claudia MartiniDepartment of Pharmacy, University of Pisa, Pisa, 56126, Italy.
Simona RapposelliDepartment of Pharmacy, University of Pisa, Pisa, 56126, Italy. simona.rapposelli@unipi.it.ORCID 0000-0003-0146-6358
University of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogen sulphide has recently drawn much attention due to its potent anti-inflammatory and neuroprotective roles in brain functions. The purpose of the current study was to exploit these beneficial properties of H

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsAutophagyCell LineHumansHydrogen SulfideInflammationMemantineMicrogliaNeuronsNeuroprotective AgentsPrimary Cell CultureProdrugsRatsRats, Sprague-DawleyAmyloid beta-PeptidesHydrogen SulfideMemantineNeuroprotective AgentsProdrugsReactive Oxygen Species

Identifiers

PMID30874573
PMCPMC6420495
OpenAlexW2921289538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.