ArticleScientific reports2019
Refractive index of human red blood cells between 290 nm and 1100 nm determined by optical extinction measurements.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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8 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.Journal of biomedical optics · 2022Pooled it
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- Assessing spectral effectiveness in color fundus photography for deep learning classification of retinopathy of prematurity.Journal of biomedical optics · 2024Article
- High-accuracy noninvasive continuous glucose monitoring using OCT angiography-purified blood scattering signals in human skin.Biomedical optics express · 2024Article
- Red Blood Cells' Area Deformation as the Origin of the Photoplethysmography Signal.Sensors (Basel, Switzerland) · 2023Article
- Morphological Characteristics, Hemoglobin Content, and Membrane Mechanical Properties of Red Blood Cell Delivery Systems.ACS applied materials & interfaces · 2022Article
- A multichannel color filter with the functions of optical sensor and switch.Scientific reports · 2021Article
- Function of Hemoglobin-Based Oxygen Carriers: Determination of Methemoglobin Content by Spectral Extinction Measurements.International journal of molecular sciences · 2021Article
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5 authors at 1 institution in 1 country.
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Abstract
The knowledge of optical properties of biological cells is essential to interpret their interaction with light and to derive morphological information and parameters associated with cell function like the oxygen transport capacity of human red blood cells (RBCs). We present a method to determine the dependence between the refractive index (RI) of human RBCs and their intracellular hemoglobin (Hb) concentration from spectral extinction measurements of a cell suspension. The procedure is based on the analysis of the corresponding ensemble averaged extinction cross section [Formula: see text]. Thus far two complementary approaches have been taken to derive RIs of RBCs. The first one uses homogeneous macroscopic samples prepared by hemolysis for the destruction of the RBCs' membranes and subsequent centrifugation. A second approach is the determination of RIs of single intact cells by microscopic investigation. These techniques are limited to a few discrete wavelengths or a rather narrow wavelength range. In addition most of these techniques require additional information about the concentration dependence. In contrast, our approach yields the RI increment with Hb concentration of intact, reversibly isovolumetrically sphered, oxygenated RBCs over a wide wavelength range from 290 nm to 1100 nm from macroscopic measurements.
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