Evidence map›Paper›PMID 30874502›Full record

ArticleeLife2019

Multiple decay events target

Patrick D Cherry, Sally E Peach, Jay R Hesselberth

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. The life and times of a tRNA.RNA (New York, N.Y.) · 2023
    Review
  8. Nanopore sequencing of internal 2'-PORNA (New York, N.Y.) · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Vps34 and TOR Kinases CoordinateMolecular and cellular biology · 2021
    Article
  13. Comparative parallel analysis of RNA ends identifies mRNA substrates of a tRNA splicing endonuclease-initiated mRNA decay pathway.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Patrick D CherryDepartment of Biochemistry and Molecular Genetics, Program in Molecular Biology, School of Medicine, University of Colorado, Aurora, United States.ORCID 0000-0001-6421-2035
Sally E PeachDepartment of Biochemistry and Molecular Genetics, Program in Molecular Biology, School of Medicine, University of Colorado, Aurora, United States.
Jay R HesselberthDepartment of Biochemistry and Molecular Genetics, Program in Molecular Biology, School of Medicine, University of Colorado, Aurora, United States.ORCID 0000-0002-6299-179X
University of Colorado Anschutz Medical Campus · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Nanopore analysis of transfer RNA forms and functionsR35GM119550 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Jay R Hesselberth · 2016 to 2026
$4.5M
Predoctoral Training Program in Molecular BiologyT32GM008730 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI PREKERIS, RYTIS, SCLAFANI, ROBERT A · 1999 to 2019
$3.3M
NCI NIH HHS P30 CA046934NIGMS NIH HHS R35 GM119550NIGMS NIH HHS T32 GM008730NIH HHS R35 GM119550NIH HHS R35GM119550NIH HHS T32 GM008730NIH HHS T32GM008730University of Colorado RNA Bioscience InitiativeUniversity of Colorado Victor W Bolie and Earleen D Bolie Graduate ScholarshipUniversity of Colorado School of Medicine RNA Bioscience Initiative
6 · The paper itself

Abstract

In the unfolded protein response (UPR), stress in the endoplasmic reticulum (ER) activates a large transcriptional program to increase ER folding capacity. During the budding yeast UPR, Ire1 excises an intron from the

Indexed as

Gene Expression Regulation, FungalRNA SplicingRNA StabilityUnfolded Protein ResponseBasic-Leucine Zipper Transcription FactorsExoribonucleasesMembrane GlycoproteinsProtein Serine-Threonine KinasesRepressor ProteinsRNA, MessengerSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsBasic-Leucine Zipper Transcription FactorsExoribonucleasesHAC1 protein, S cerevisiaeIRE1 protein, S cerevisiaeMembrane GlycoproteinsProtein Serine-Threonine KinasesRepressor ProteinsRNA, MessengerSaccharomyces cerevisiae ProteinsXRN1 protein, S cerevisiaechromosomesgene expressionRNA decayRNA repairS. cerevisiaeunfolded protein response

Identifiers

PMID30874502
PMCPMC6456296
OpenAlexW2949173987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.