ArticleRNA biology2019
Circular RNAs in human and vertebrate neural retinas.
Article in RNA biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- circASbase: A Comprehensive Database of Alternative Splicing Events in circRNAs.Genomics, proteomics & bioinformatics · 2026Article
- Uncovering the new landscape of leukoaraiosis through the circular RNA-miRNA-mRNA axis.Frontiers in neurology · 2025Article
- RNA fusion in human retinal development.eLife · 2024Article
- Assessment of different enrichment methods revealed the optimal approach to identify bovine circRnas.RNA biology · 2024Article
- Retinitis pigmentosa-associated mutations in mouse Prpf8 cause misexpression of circRNAs and degeneration of cerebellar granule cells.Life science alliance · 2023Article
- The Role of MiR-181 Family Members in Endothelial Cell Dysfunction and Tumor Angiogenesis.Cells · 2022Review
- Genome-wide identification and functional analysis of circRNAs in Trichophyton rubrum conidial and mycelial stages.BMC genomics · 2022Article
- Involvement of CircRNA Expression Profile in Diabetic Retinopathy and Its Potential Diagnostic Value.Frontiers in genetics · 2022Article
- Expression and function of circular RNAs in the mammalian brain.Cellular and molecular life sciences : CMLS · 2021Review
- Circular RNAs in the Central Nervous System.Frontiers in molecular biosciences · 2021Review
- Revealing Epigenetic Factors of circRNA Expression by Machine Learning in Various Cellular Contexts.iScience · 2020Article
- Review
- The Circular RNome of Developmental Retina in Mice.Molecular therapy. Nucleic acids · 2020Article
- Article
- Identification of Candidate Circular RNAs Underlying Intramuscular Fat Content in the Donkey.Frontiers in genetics · 2020Article
- CircRNA Is a Rising Star in Researches of Ocular Diseases.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular RNAs (circRNAs) belong to an endogenous class of RNA molecules with both ends covalently linked in a circle. Although their expression pattern in the mammalian brain has been well studied, the characteristics and functions of circRNAs in retinas remain unknown. To reveal the whole expression profiles of circRNAs in the neural retina, we investigated retinal RNAs of human, monkey, mouse, pig, zebrafish and tree shrew and detected thousands of circRNAs showing conservation and variation in the retinas across different vertebrate species. We further investigated one of the abundant circRNAs, circPDE4B, identified in human retina. Silencing of circPDE4B significantly inhibited the proliferation of human A549 cells. Functional assays demonstrated that circPDE4B could sponge miR-181C, thereby altering the cell phenotype. We have explored the retinal circRNA repertoires across human and different vertebrates, which provide new insights into the important role of circRNAs in the vertebrate retinas, as well as in related human diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.