Evidence map›Paper›PMID 30874350›Full record

ReviewImmunological reviews2019

T follicular helper cell heterogeneity: Time, space, and function.

Wenzhi Song, Joe Craft

Abstract readReview
In one paragraph

Review in Immunological reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 195 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Adult T-cell leukaemia/lymphoma with different histological features in a single lymph node.Journal of clinical and experimental hematopathology : JCEH · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Circulating TFH2 Cell Expansion and GZMKJournal of asthma and allergy · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wenzhi SongDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT.
Joe CraftDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT.ORCID 0000-0002-1368-6756
Yale University · US

Funding

IMMUNE RESPONSES IN LUPUSR37AR040072 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2000 to 2025
$7.4M
Cis Regulatory Elements and Systemic Lupus ErythematosusR01AR068994 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR, GALLAGHER, PATRICK G · 2016 to 2020
$2.7M
Follicular Helper T Cell Function in AutoimmunityR01AR074545 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2019 to 2022
$1.3M
An in vivo CRISPR-Cas9 genetic screen in murine primary T cells to discover metabolic regulators of follicular B helper T (Tfh) cell differentiationR61AR073048 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR, FLAVELL, RICHARD A · 2017 to 2018
$810k
NIAMS NIH HHS R01 AR068994NIAMS NIH HHS R01 AR074545NIAMS NIH HHS R37 AR040072NIAMS NIH HHS R61 AR073048NIH HHS R61 AR073948
6 · The paper itself

Abstract

T follicular helper (Tfh) cells play a crucial role in orchestrating the humoral arm of adaptive immune responses. Mature Tfh cells localize to follicles in secondary lymphoid organs (SLOs) where they provide help to B cells in germinal centers (GCs) to facilitate immunoglobulin affinity maturation, class-switch recombination, and generation of long-lived plasma cells and memory B cells. Beyond the canonical GC Tfh cells, it has been increasingly appreciated that the Tfh phenotype is highly diverse and dynamic. As naive CD4

Indexed as

AnimalsAntibody AffinityB-LymphocytesCell DifferentiationCell PlasticityGerminal CenterHumansImmunity, HumoralImmunologic MemoryPlasma CellsT-Lymphocytes, Helper-InducerT-Lymphocyte Subsetsgerminal centerT cell differentiationT cell migrationT follicular helper cells

Identifiers

PMID30874350
PMCPMC6422039
OpenAlexW2921047712

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.