ArticleBritish journal of pharmacology2019
Discovery of early life stress interacting and sex-specific quantitative trait loci impacting cocaine responsiveness.
Article in British journal of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Sex differences in stress-modulated cocaine vulnerability: female rodents are more sensitive to the effects of stress exposure at different developmental stages.Frontiers in behavioral neuroscience · 2025Review
- Effects of isolation housing stress and mouse strain on intravenous cocaine self-administration, sensory stimulus self-administration, and reward preference.Scientific reports · 2023Article
- Intravenous fentanyl self-administration in male and female C57BL/6J and DBA/2J mice.Scientific reports · 2023Article
- Extreme phenotypic diversity in operant response to intravenous cocaine or saline infusion in the hybrid mouse diversity panel.Addiction biology · 2022Article
- Working memory and pattern separation in founder strains of the BXD recombinant inbred mouse panel.Scientific reports · 2022Article
- Daidzein modulates cocaine-reinforcing effects and cue-induced cocaine reinstatement in CD-1 male mice.Psychopharmacology · 2021Article
- Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis.Genes, brain, and behavior · 2020Review
- Discovery of early life stress interacting and sex-specific quantitative trait loci impacting cocaine responsiveness.British journal of pharmacology · 2019Article
- The importance of sex differences in pharmacology research.British journal of pharmacology · 2019Article
- Strain differences in maternal neuroendocrine and behavioral responses to stress and the relation to offspring cocaine responsiveness.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2019Article
- Visual Discrimination, Serial Reversal, and Extinction Learning in theFrontiers in behavioral neuroscience · 2019Article
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Authors and funding
3 authors.
Funding
Abstract
background and purposeAddiction vulnerability involves complex gene X environment interactions leading to a pathological response to drugs. Identification of the genes involved in these interactions is an important step in understanding the underlying neurobiology and rarely have such analyses examined sex-specific influences. To dissect this interaction, we examined the impact of prenatal stress (PNS) on cocaine responsiveness in male and female mice of the BXD recombinant inbred panel. EXPERIMENTAL APPROACH: BXD strains were subjected to timed mating and assigned to PNS or control groups. PNS dams were subjected to restraint stress (1-hr restraint, three times daily) starting between embryonic day (E) 11 and 14 and continued until parturition. Adult male and female, control and PNS offspring were tested for locomotor response to initial and repeated cocaine injections (sensitization) as well as cocaine-induced conditioned place preference (CPP). KEY
resultsStrain, PNS, and sex interacted to modulate initial and sensitized cocaine-induced locomotion, as well as CPP. Moreover, a quantitative trait locus (QTL) interacting with PNS regulating initial locomotor response to cocaine (chromosome X, 37.91 to 50.95 Mb) was identified. Also PNS-independent, female-specific QTLs regulating CPP (chromosome 11, 65.50 to 81.31 Mb) and sensitized cocaine-induced locomotion (chromosome 16, 95.79 to 98.32 Mb) were identified. Publicly available mRNA expression data were utilized to identify cis-eQTL and transcript covariation with the behavioural phenotype to prioritize candidate genes; including Aifm1. CONCLUSIONS AND IMPLICATIONS: These QTL encompass genes that may moderate genetic susceptibility to PNS and interact with sex to determine adult responsiveness to cocaine and addiction vulnerability. LINKED ARTICLES: This article is part of a themed section on The Importance of Sex Differences in Pharmacology Research. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.21/issuetoc.
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