SynthesisAnnals of global health2018
Environmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review.
Synthesis in Annals of global health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Stress During Pregnancy and Epigenetic Modifications to Offspring DNA: A Systematic Review of Associations and Implications for Preterm Birth.The Journal of perinatal & neonatal nursingPooled it
- Effects of Exposure to Extreme Artificial Light at Night on Liver Oxidative Damage and Gut Microbiota During Pregnancy and Lactation in Mice.Animals : an open access journal from MDPI · 2026Article
- Climate change, environmental exposures, and breast cancer: advancing climate-resilient oncology through sustainable development goal 13.Frontiers in public health · 2026Review
- DNA methylation as a biomarker of prenatal exposures: current challenges and opportunities.Environmental epigenetics · 2026Review
- Epigenetic reprogramming by air pollution: linking prenatal exposures to birth outcomes.Molecular and cellular biochemistry · 2025Review
- Immune-Epigenetic Effects of Environmental Pollutants: Mechanisms, Biomarkers, and Transgenerational Impact.Current issues in molecular biology · 2025Review
- Exploring the link between environmental chemical exposures and epigenetic modifications in diabetes mellitus: A review.Biomolecules & biomedicine · 2025Review
- Sex-specific role of epigenetic modification of a leptin upstream enhancer in adipose tissue.Clinical epigenetics · 2025Article
- Histone Deacetylase Inhibitors Restore the Odontogenic Differentiation Potential of Dental Pulp Stem Cells under Hyperglycemic Conditions.Current stem cell research & therapy · 2025Article
- Multi-omic integration reveals alterations in nasal mucosal biology that mediate air pollutant effects on allergic rhinitis.Allergy · 2024Article
- Polycyclic aromatic hydrocarbon exposure effects on trajectories of maternal and adolescent mental health.Child and adolescent psychiatry and mental health · 2024Article
- Prenatal Arsenic Exposure on DNA Methylation ofToxics · 2024Article
- Epigenetics as a target to mitigate excess stroke risk in people of African ancestry: A scoping review.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2024Article
- Associations between Urinary Mercury/Cadmium Concentrations and Anthropometric Features in Korean Children.Toxics · 2024Article
- Persistent gene expression and DNA methylation alterations linked to carcinogenic effects of dichloroacetic acid.Frontiers in oncology · 2024Article
- From womb to wellness: early environmental exposures, cord blood DNA methylation and disease origins.Epigenomics · 2024Review
- Gene-environment interactions in Alzheimer disease: the emerging role of epigenetics.Nature reviews. Neurology · 2022Review
- Associations between infant sex and DNA methylation across umbilical cord blood, artery, and placenta samples.Epigenetics · 2022Article
- Decreased Levels of DNA Methylation in the PCDHA Gene Cluster as a Risk Factor for Early-Onset High Myopia in Young Children.Investigative ophthalmology & visual science · 2022Article
- DNA methylation: a potential mediator between air pollution and metabolic syndrome.Clinical epigenetics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren are susceptible to environmental contaminants and are at risk of developing diseases, more so if the exposure begins at an early age. Epidemiological studies have postulated the hypothesis of the fetal origin of disease, which is mediated by epigenetic changes. Epigenetic marks are inheritable; they modulate the gene expression and can affect human health due to the presence of environmental factors.
objectiveThis review focuses on DNA-methylation and its association with environmental-related diseases in children.
methodsA search for studies related to DNA-methylation in children by pre- or post-natal environmental exposures was conducted, and those studies with appropriate designs and statistical analyses and evaluations of the exposure were selected.
findingsPrenatal and early life environmental factors, from diet to exposure to pollutants, have been associated with epigenetic changes, specifically DNA-methylation. Thus, maternal nutrition and smoking and exposure to air particulate matter, polycyclic aromatic hydrocarbons, arsenic, heavy metals, persistent organic pollutants, and some endocrine disrupters during pregnancy have been associated with genomic and gene-specific newborns' DNA-methylation changes that have shown in some cases sex-specific patterns. In addition, these maternal factors may deregulate the placental DNA-methylation balance and could induce a fetal reprogramming and later-in-life diseases.
conclusionsExposure to environmental pollutants during prenatal and early life can trigger epigenetic imbalances and eventually the development of diseases in children. The integration of epigenetic data should be considered in future risk assessments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.