Evidence map›Paper›PMID 30873592›Full record

ReviewClinical and experimental immunology2019

Sculpting tumor microenvironment with immune system: from immunometabolism to immunoediting.

Y-R Yu, P-C Ho

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical and experimental immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
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  18. Comparative Analysis of Vaginal Microbiota in Women with Breast Cancer in Kazakhstan.Asian Pacific journal of cancer prevention : APJCP · 2021
    Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Y-R YuDepartment of Fundamental Oncology, University of Lausanne, Epalinges, Switzerland.
P-C HoDepartment of Fundamental Oncology, University of Lausanne, Epalinges, Switzerland.ORCID 0000-0003-3078-3774

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer immunotherapy unleashing the power of host immunity on eliminating cancer cells represents a critical advance in cancer treatment; however, effective anti-tumor responses are largely dampened by the immunosuppressive tumor microenvironment (TME). Emerging studies have revealed that physiological features in the TME, including glucose deprivation, hypoxia and low pH, established by the metabolically dysregulated cancer cells restrict anti-tumor immunity by impeding the metabolic fitness of tumor-infiltrating cytotoxic CD8

Indexed as

Tumor EscapeTumor MicroenvironmentAnimalsCD8-Positive T-LymphocytesHumansImmune SystemImmunityImmunomodulationKiller Cells, NaturalNeoplasmsimmunoeditingimmunometabolismtumor microenvironment

Identifiers

PMID30873592
PMCPMC6642881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.