ArticleInternational journal of cancer2019
The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies.
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Article in International journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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17citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Adiposity and risk of prostate cancer death: a prospective analysis in UK Biobank and meta-analysis of published studies.BMC medicine · 2022Pooled it
- Effects of Dietary or Supplementary Micronutrients on Sex Hormones and IGF-1 in Middle and Older Age: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Adiposity and cancer: epidemiology, mechanisms and future perspectives.Nature metabolism · 2026Review
- Obesity, metformin prescription and risk of advanced prostate cancer in non-diabetic men.BJC reports · 2026Article
- Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis.Journal of the National Cancer Institute · 2025Article
- CYR61 Expression Is Induced by IGF1 and Promotes the Proliferation of Prostate Cancer Cells Through the PI3/AKT Signaling Pathway.International journal of molecular sciences · 2025Article
- IGFBP-1 and IGF-I in relation to adiposity and mortality from midlife to old age in the Swedish Adoption/Twin Study of Aging.International journal of obesity (2005) · 2025Article
- Aging and IGF-I: relationships with vitamin D and body composition. A mediation analysis.Frontiers in nutrition · 2025Article
- Causal Effects of Smoking, Alcohol, Coffee, and Tea Intake on Gynecologic Cancers: A Mendelian Randomization Study.International journal of women's health · 2025Article
- Associations of body composition measures with circulating insulin-like growth factor-I, testosterone, and sex hormone-binding globulin concentrations in 16,000 men.International journal of obesity (2005) · 2024Article
- Article
- Combination of Waist Circumference and Circulating Levels of IGFBP-2 as a Simple Screening Tool for Early Detection of Metabolic Dysfunction-Associated Steatotic Liver Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- The accelerated aging phenotype: The role of race and social determinants of health on aging.Ageing research reviews · 2022Review
- Physical activity in relation to circulating hormone concentrations in 117,100 men in UK Biobank.Cancer causes & control : CCC · 2021Article
- Associations of circulating insulin-like growth factor-I with intake of dietary proteins and other macronutrients.Clinical nutrition (Edinburgh, Scotland) · 2021Observational
- Insulin-Like Growth Factor-II and Ischemic Stroke-A Prospective Observational Study.Life (Basel, Switzerland) · 2021Article
- Epidemiology of Anthropometric Factors in Glioblastoma Multiforme-Literature Review.Brain sciences · 2021Review
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Authors and funding
64 authors at 20 institutions in 15 countries.
Eleanor L WattsCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-9229-2589
Aurora Perez-CornagoCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Paul N ApplebyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Eva ArdanazNavarra Public Health Institute, Pamplona, Spain.
Amanda BlackDivision of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD.
H Bas Bueno-de-MesquitaDepartment for Determinants of Chronic Diseases, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
June M ChanDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA.
Chu ChenPublic Health Sciences Division, Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA.
S A Paul ChubbPathWest Laboratory Medicine, Fiona Stanley Hospital, Perth, WA, Australia.
Michael B CookDivision of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Mélanie DeschasauxSorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Nutritional Epidemiology Research Team (EREN), Inserm U1153/Inra U1125/Cnam/Paris 13 University, Paris, France.
Jenny L DonovanDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Dallas R EnglishCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Leon FlickerMedical School, University of Western Australia, Perth, WA, Australia.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Pilar GalanSorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Nutritional Epidemiology Research Team (EREN), Inserm U1153/Inra U1125/Cnam/Paris 13 University, Paris, France.
Graham G GilesCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Edward L GiovannucciDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Marc J GunterSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Laurel A HabelDivision of Research, Kaiser Permanente Northern California, Oakland, CA.
Christel HäggströmDepartment of Biobank Research, Umeå University, Umeå, Sweden.ORCID 0000-0001-6808-4405
Christopher HaimanKeck School of Medicine, University of Southern California, Los Angeles, CA.
Freddie C HamdyNuffield Department of Surgery, University of Oxford, Oxford, United Kingdom.
Serge HercbergSorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Nutritional Epidemiology Research Team (EREN), Inserm U1153/Inra U1125/Cnam/Paris 13 University, Paris, France.
Jeff M HollyIGFs & Metabolic Endocrinology Group, Translational Health Sciences, Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol, United Kingdom.
Jiaqi HuangDivision of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-7808-9477
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-4440-3368
Mattias JohanssonGenetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Tatsuhiko KuboDepartment of Environmental Epidemiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
J Athene LaneDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Tracy M LayneIcahn School of Medicine at Mount Sinai, New York, NY.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI.
Richard M MartinDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
E Jeffrey MetterDepartment of Neurology, University of Tennessee Health Science Center, Memphis, TN.
Kazuya MikamiJapanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan.
Roger L MilneCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Howard A MorrisChemical Pathology Directorate, SA Pathology, Adelaide, SA, Australia.
Lorelei A MucciDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
David E NealNuffield Department of Surgery, University of Oxford, Oxford, United Kingdom.
Marian L NeuhouserCancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Steven E OliverDepartment of Health Sciences, University of York and the Hull York Medical School, York, UK.
Kim OvervadDepartment of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.
Kotaro OzasaRadiation Effects Research Foundation, Hiroshima, Japan.
Valeria PalaEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Claire H PernarDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Michael PollakDepartment of Medicine and Oncology, McGill University, Montreal, QC, Canada.
Mari-Anne RowlandsDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Catherine A SchaeferDivision of Research, Kaiser Permanente Northern California, Oakland, CA.
Jeannette M SchenkCancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Pär StattinDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Akiko TamakoshiHokkaido University Faculty of Medicine, Hokkaido, Japan.
Elin ThysellDepartment of Medical Biosciences and Pathology, Umea University, Umea, Sweden.
Mathilde TouvierSorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Nutritional Epidemiology Research Team (EREN), Inserm U1153/Inra U1125/Cnam/Paris 13 University, Paris, France.
Antonia TrichopoulouHellenic Health Foundation, Athens, Greece.
Konstantinos K TsilidisDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.ORCID 0000-0002-8452-8472
Stephen K Van Den EedenDivision of Research, Kaiser Permanente Northern California, Oakland, CA.
Stephanie J WeinsteinDivision of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Lynne WilkensUniversity of Hawaii Cancer Center, Honolulu, HI.
Bu B YeapMedical School, University of Western Australia, Perth, WA, Australia.
Timothy J KeyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Naomi E AllenClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
National Institutes of Health · USUniversity of Oxford · GBInserm · FRCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAKaiser Permanente · USThe University of Melbourne · AUThe University of Western Australia · AUUniversity of Bristol · GBBrigham and Women's Hospital · USCentre international de recherche sur le cancer · FRNuffield Orthopaedic Centre · GBUmeå University · SEUniversity of Hawaiʻi at Mānoa · USAarhus University · DKBristol City Council · GBFondazione IRCCS Istituto Nazionale dei Tumori · ITGerman Cancer Research Center · DEHarvard University · USHellenic Health Foundation · GRHokkaido University of Science · JP
Funding
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MPLCO Trial Etiologic and Early Marker StudyZIACP010152 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MOORE, STEVEN · 2009 to 2025
$29.9MCancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0MUnderstanding Ethnic Differences in Cancer: The Multiethnic Cohort StudyUM1CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HENDERSON, BRIAN E, LE MARCHAND, LOIC · 2012 to 2014
$11.3MCancer Research UK 16491Cancer Research UK 19169Cancer Research UK 19170Cancer Research UK A19169Cancer Research UK A20986Cancer Research UK C18281/A19169Cancer Research UK C8221/A19170Cancer Research UK C8221/A20986Department of HealthMedical Research Council G0700474Medical Research Council G9900923Medical Research Council MR/K02700X/1NCI NIH HHS P30 CA071789NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA167552NCI NIH HHS UG1 CA189974NCI NIH HHS UM1 CA164973World Health Organization 001
Abstract
Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.
Indexed as
AdultAgedAged, 80 and overAnthropometryBiomarkers, TumorCross-Sectional StudiesHumansInsulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IInsulin-Like Growth Factor IIMaleMiddle AgedNeoplasmsProspective StudiesYoung AdultBiomarkers, TumorInsulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IInsulin-Like Growth Factor IIcorrelatesIGFBPsIGFspooled analysis
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