Evidence map›Paper›PMID 30873506›Full record

ArticleBioactive materials2019

Polydopamine and collagen coated micro-grated polydimethylsiloxane for human mesenchymal stem cell culture.

Dhavan Sharma, Wenkai Jia, Fei Long, Shweta Pati, Qinghui Chen, Yibing Qyang, Bruce Lee, Chang Kyong Choi, Feng Zhao

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 83 citations in OpenAlex.

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  13. Comparison of the Impact of NaIOACS applied materials & interfaces · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dhavan SharmaDepartment of Biomedical Engineering, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Wenkai JiaDepartment of Biomedical Engineering, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Fei LongDepartment of Mechanical Engineering-Engineering Mechanics, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Shweta PatiDepartment of Biomedical Engineering, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Qinghui ChenDepartment of Kinesiology and Integrative Physiology, Department of Kinesiology and Integrative Physiology, Houghton, MI, 49931, USA.
Yibing QyangYale Stem Cell Center, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA.
Bruce LeeDepartment of Biomedical Engineering, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Chang Kyong ChoiDepartment of Biomedical Engineering, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Feng ZhaoDepartment of Biomedical Engineering, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Michigan Technological University · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Human tissue-engineered blood vessels using induced pluripotent stem cellsR01HL116705 · NHLBI · YALE UNIVERSITY · PI QYANG, YIBING · 2013 to 2017
$2.0M
Biomechanical Signaling in Human Familial Hypertrophic CardiomyopathyR01HL131940 · NHLBI · YALE UNIVERSITY · PI QYANG, YIBING · 2016 to 2019
$1.7M
Therapeutic Lymphatic Vessel RegenerationR15CA202656 · NCI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI ZHAO, FENG · 2016 to 2016
$465k
Development of Off-the-shelf Completely Biological Small-Diameter Blood Vessel wiR15HL115521 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI ZHAO, FENG · 2013 to 2013
$410k
NCATS NIH HHS UL1 TR001863NCI NIH HHS R15 CA202656NHLBI NIH HHS R01 HL116705NHLBI NIH HHS R01 HL131940NHLBI NIH HHS R15 HL115521
6 · The paper itself

Abstract

Natural tissues contain highly organized cellular architecture. One of the major challenges in tissue engineering is to develop engineered tissue constructs that promote cellular growth in physiological directionality. To address this issue, micro-patterned polydimethylsiloxane (PDMS) substrates have been widely used in cell sheet engineering due to their low microfabrication cost, higher stability, excellent biocompatibility, and most importantly, ability to guide cellular growth and patterning. However, the current methods for PDMS surface modification either require a complicated procedure or generate a non-uniform surface coating, leading to the production of poor-quality cell layers. A simple and efficient surface coating method is critically needed to improve the uniformity and quality of the generated cell layers. Herein, a fast, simple and inexpensive surface coating method was analyzed for its ability to uniformly coat polydopamine (PD) with or without collagen on micro-grated PDMS substrates without altering essential surface topographical features. Topographical feature, stiffness and cytotoxicity of these PD and/or collagen based surface coatings were further analyzed. Results showed that the PD-based coating method facilitated aligned and uniform cell growth, therefore holds great promise for cell sheet engineering as well as completely biological tissue biomanufacturing.

Indexed as

CollagenHuman mesenchymal stem cellMicro-gratingPolydimethylsiloxanePolydopamine

Identifiers

PMID30873506
PMCPMC6400012
OpenAlexW2947667055

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.