Evidence map›Paper›PMID 30873503›Full record

ArticleChem2019

Providing a New Aniline Bioisostere through the Photochemical Production of 1-Aminonorbornanes.

Daryl Staveness, Taylor M Sodano, Kangjun Li, Elizabeth A Burnham, Klarissa D Jackson, Corey R J Stephenson

Abstract read
In one paragraph

Article in Chem, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Exploiting Imine Photochemistry for Masked N-Centered Radical Reactivity.Angewandte Chemie (International ed. in English) · 2019
    Article
  15. Article
  16. Illuminating Photoredox Catalysis.Trends in chemistry · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daryl StavenessDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Taylor M SodanoDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Kangjun LiDepartment of Pharmaceutical Sciences, Lipscomb University, Nashville, TN 37204, USA.
Elizabeth A BurnhamDepartment of Pharmaceutical Sciences, Lipscomb University, Nashville, TN 37204, USA.
Klarissa D JacksonDepartment of Pharmaceutical Sciences, Lipscomb University, Nashville, TN 37204, USA.
Corey R J StephensonDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

Funding

Photochemical synthesis of bioactive moleculesR01GM127774 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STEPHENSON, COREY · 2018 to 2021
$1.9M
Role of Cytochrome P450 3A5 in the Metabolism and Hepatotoxicity of LapatinibK01CA190711 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JACKSON, KLARISSA D · 2014 to 2018
$659k
NCI NIH HHS K01 CA190711NIGMS NIH HHS R01 GM127774
6 · The paper itself

Abstract

This report describes the photochemical conversion of aminocyclopropanes into 1-aminonorbornanes via formal [3+2] cycloadditions initiated by homolytic fragmentation of amine radical cation intermediates. Aligning with the modern movement toward

Indexed as

1-aminonorbornaneamine radical cationAminocyclopropanebioisosterehomolytic fragmentationmetabolic stabilityphotoredox catalysisradical cyclization

Identifiers

PMID30873503
PMCPMC6411061

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.