ArticleJournal of clinical and translational research2018
Inclusion of special populations in clinical research: important considerations and guidelines.
Article in Journal of clinical and translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Results and Strategies for a Diversity-Oriented Public Health Monitoring in Germany.International journal of environmental research and public health · 2022Pooled it
- Increasing engagement of Spanish-speaking transgender Latinas in research: strategies from ChiCAS, a community-based participatory research intervention trial.Health education research · 2025Trial
- Practical considerations for dense longitudinal neuroimaging: Ten simple rules for frequent scanning over short time periods.Developmental cognitive neuroscience · 2026Article
- Guiding principles for clinical research on substance use disorders in rural communities.Journal of substance use and addiction treatment · 2026Article
- Article
- Bridging disciplinary siloes: a scoping review on the inclusion and exclusion of pregnant and lactating populations in clinical research.BMJ public health · 2026Article
- Insights from the development of an online toolkit to promote community-engaged substance use research in the Southwest Borderlands Region.Journal of clinical and translational science · 2026Article
- Challenges and opportunities in clinical field research: A Bourdieusian analysis of Fiocruz's experience in Brazil.PloS one · 2026Article
- Community leaders' perceptions of pain and research engagement: Implications for participant diversity and inclusion in pain clinical trials.The journal of pain · 2025Article
- Exploring recruitment strategies for place-based research in rural areas of Australia: a comparative case study analysis.BMC primary care · 2025Article
- Community Perspectives on Factors That Improve Young Men's Participation in Rural Research.Ethnicity & disease · 2025Article
- Preferences for clinical trial participation among people who use drugs in rural Oregon and Appalachian Ohio.Drug and alcohol dependence · 2025Article
- Insights from the development of an online toolkit to promote community engaged substance use research in the Southwest Borderlands Region.Research square · 2025Article
- Evaluating representativeness: recruitment for a virtual family-based intervention focused on the transition from pediatric to adult diabetes care†.Journal of pediatric psychology · 2025Article
- Harnessing Mother's Strengths to THRIVE in Obesity Prevention Efforts: A Qualitative Study.Clinical practice in pediatric psychology · 2025Article
- The roadmap to integrate diversity, equity, and inclusion in hematology clinical trials: an American Society of Hematology initiative.Blood advances · 2025Article
- Managing Atopic Dermatitis with Dupilumab in Special Populations: A Case Series Study.Clinical, cosmetic and investigational dermatology · 2025Article
- Community engagement strategies improve recruitment and enrollment in a pragmatic clinical trial.Journal of clinical and translational science · 2025Article
- Informed consent: Navigating the bioethical complexities of clinical research.Bioinformation · 2025Article
- Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTrials that involve human participants call for experiments or observations that are performed in a clinical research setting. Currently, there are over 16,000 clinical trials open in the United States. Despite continuing efforts to include "special populations" in clinical trials, there are gaps in participation for people who are either minors or elderly adults, are from historically under-represented minorities, or live in rural communities. The inclusion of these special populations in clinical trials research is essential for conclusions that benefit all populations. Data suggest that study partic-ipation rates for special populations have fallen to levels that could endanger the successful performance of some types of research. This is particularly concerning in the 21st century, where demographic trends in the United States continue to shift towards an older and Hispanic population with fewer rural dwellers. Trends in New Mexico and other minority-majority states mirror many of these shifts. RELEVANCE FOR PATIENTS: In this review, we highlight improvement strategies for enhanced clinical trial participation by members of special populations. Key drivers for disparate clinical trials participation and outcomes often include differences in genetics, physiology, and perceptions of mistrust towards researchers. To overcome these barriers, we focus on best practices in recruitment strategies from the perspectives of the participants, the researchers and the institutions that support clinical trials.
Indexed as
Identifiers
30873495PMC6410628W2995167968What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.