ReviewBeilstein journal of organic chemistry2019
Back to the future: Why we need enzymology to build a synthetic metabolism of the future.
Review in Beilstein journal of organic chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Metabolism-inspired chemical reaction networks for chemically driven dissipative oligoesterification.Angewandte Chemie (International ed. in English) · 2025Article
- A pilot oral history of plant synthetic biology.Plant physiology · 2024Review
- Pickaxe: a Python library for the prediction of novel metabolic reactions.BMC bioinformatics · 2023Article
- Carbon-negative production of acetone and isopropanol by gas fermentation at industrial pilot scale.Nature biotechnology · 2022Article
- Experimental and computational investigation of enzyme functional annotations uncovers misannotation in the EC 1.1.3.15 enzyme class.PLoS computational biology · 2021Article
- In-Depth Computational Analysis of Natural and Artificial Carbon Fixation Pathways.Biodesign research · 2021Article
- Bioengineering horizon scan 2020.eLife · 2020Article
- Engineering Improved Photosynthesis in the Era of Synthetic Biology.Plant communications · 2020Review
- Sensitive Oligodeoxynucleotide Synthesis Using Dim and Dmoc as Protecting Groups.The Journal of organic chemistry · 2019Article
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Authors and funding
1 author.
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Abstract
Biology is turning from an analytical into a synthetic discipline. This is especially apparent in the field of metabolic engineering, where the concept of synthetic metabolism has been recently developed. Compared to classical metabolic engineering efforts, synthetic metabolism aims at creating novel metabolic networks in a rational fashion from bottom-up. However, while the theoretical design of synthetic metabolic networks has made tremendous progress, the actual realization of such synthetic pathways is still lacking behind. This is mostly because of our limitations in enzyme discovery and engineering to provide the parts required to build synthetic metabolism. Here I discuss the current challenges and limitations in synthetic metabolic engineering and elucidate how modern day enzymology can help to build a synthetic metabolism of the future.
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Registered trials
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