Evidence map›Paper›PMID 30873220›Full record

ArticleDiabetology & metabolic syndrome2019

Differential role of insulin resistance and β-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese population.

Xueli Cai, Lili Xia, Yuesong Pan, Dian He, Huiping Zhu, Tiemin Wei, Yan He

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Article in Diabetology & metabolic syndrome, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xueli Cai *Department of Neurology, Lishui Municipal Central Hospital, Lishui, Zhejiang China.
Lili Xia *2Editorial Office of Hepatobiliary and Pancreatic Diseases International, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Yuesong Pan3Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Dian He4Department of Epidemiology and Biostatics, School of Public Health, Capital Medical University, Beijing, China.
Huiping Zhu4Department of Epidemiology and Biostatics, School of Public Health, Capital Medical University, Beijing, China.
Tiemin WeiDepartment of Neurology, Lishui Municipal Central Hospital, Lishui, Zhejiang China.
Yan He4Department of Epidemiology and Biostatics, School of Public Health, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of diabetes and prediabetes were estimated to be 10.9% and 35.7% in the Chinese adult population, respectively, and the middle-aged and elderly Chinese are at even higher risk of diabetes and prediabetes than younger population. With the increasing trend of aging in China, the burden of diabetes and related complications will be aggravated.

objectivesThrough comparing the indices of insulin resistance and β-cell function between subjects with different glucose metabolic status, to analyze the differential role of insulin resistance and β-cell function in the development of prediabetes and type 2 diabetes (T2DM) in the middle-aged and elderly Chinese population.

methodsIn this cross-sectional study, we enrolled 512 participants aged 50 and over. The indices of insulin resistance (homoeostasis model assessment of insulin resistance (HOMA-IR) and adipose tissue insulin resistance (Adipo-IR), and indices of β-cell function [HOMA-β), fasting C-peptide to glucose ratio (FCPRI) and postprandial C-peptide to glucose ratio (PCPRI)] were calculated. Association of insulin resistance and β-cell function with prediabetes or T2DM were evaluated by multivariate logistic regression analysis, in which potential confounding factors were adjusted.

resultsOf the 509 participants with complete information, 263 (51.7%) had normal glucose tolerance (NGT), 161 (31.6%) were in prediabetic status and 85 (16.7%) were overt T2DM. With the advancing of unfavorable glucose metabolism, the insulin resistance (HOMA-IR and Adipo-IR) and β-cell function (FCPRI, PCPRI) deteriorated (

conclusionsInsulin resistance is the main determinant of developing prediabetes, whereas β-cell function is the main determinant of developing T2DM.

Indexed as

Adipose tissue insulin resistancePeripheral tissue insulin resistancePrediabetesType 2 diabetesβ-Cell function

Identifiers

PMID30873220
PMCPMC6402147

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