ReviewFrontiers in neuroscience2019
Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains.
Review in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Direct neuronal reprogramming: emerging therapeutic strategies for neurodegenerative disorders.Annals of medicine · 2026Review
- A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease-Like Non-Human Primate Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Art of Nanoimmunobiotechnomedicine in Depression Management.Advanced pharmaceutical bulletin · 2025Review
- Neuroinflammation-A Crucial Factor in the Pathophysiology of Depression-A Comprehensive Review.Biomolecules · 2025Review
- Neural stem cells persist to generate new neurons in the hippocampus of adult and aged human brain - Fiction or accurate?Ageing research reviews · 2023Review
- Polypyrimidine tract binding protein knockdown reverses depression-like behaviors and cognition impairment in mice with lesioned cholinergic neurons.Frontiers in aging neuroscience · 2023Article
- Inducible motor neuron differentiation of human induced pluripotent stem cells in vivo.Cell proliferation · 2022Article
- Unexpected BrdU inhibition on astrocyte-to-neuron conversion.Neural regeneration research · 2022Article
- Limited astrocyte-to-neuron conversion in the mouse brain using NeuroD1 overexpression.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Targeting PTB for Glia-to-Neuron Reprogramming In Vitro and In Vivo for Therapeutic Development in Neurological Diseases.Biomedicines · 2022Review
- Reprogramming Glial Cells into Functional Neurons for Neuro-regeneration: Challenges and Promise.Neuroscience bulletin · 2021Review
- In vivo glial trans-differentiation for neuronal replacement and functional recovery in central nervous system.The FEBS journal · 2021Review
- Review
- Adult neurogenesis from reprogrammed astrocytes.Neural regeneration research · 2020Review
- Differential neuronal reprogramming induced by NeuroD1 from astrocytes in grey matterNeural regeneration research · 2020Article
- Neurocognitive Decline Following Radiotherapy: Mechanisms and Therapeutic Implications.Cancers · 2020Review
- Regeneration of Functional Neurons After Spinal Cord Injury viaFrontiers in cell and developmental biology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult neurogenesis has been extensively studied in rodent animals, with distinct niches found in the hippocampus and subventricular zone (SVZ). In non-human primates and human postmortem samples, there has been heated debate regarding adult neurogenesis, but it is largely agreed that the rate of adult neurogenesis is much reduced comparing to rodents. The limited adult neurogenesis may partly explain why human brains do not have self-repair capability after injury or disease. A new technology called "
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.