ArticleScientific reports2019
Single cell RNA-seq study of wild type and Hox9,10,11 mutant developing uterus.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- Wnt5a Regulates Embryonic Müllerian Duct Development Through the Non-Canonical Wnt PCP Pathway.Cells · 2026Article
- A mesothelial differentiation gateway drives fibrosis.Nature communications · 2025Article
- The Role of β-Core Fragment hCG in Embryo Implantation and Early Pregnancy.International journal of molecular sciences · 2025Article
- Active chromatin marks and up-regulation of FOXC1 in uterine epithelial cells demarcate the onset of reproductive decline in aging females.NAR molecular medicine · 2025Article
- Genetic variation and molecular profiling of congenital malformations of the female genital tract based on whole-genome sequencing.World journal of pediatrics : WJP · 2024Article
- Article
- Secretion of WNT7A by UC-MSCs assist in promoting the endometrial epithelial regeneration.iScience · 2024Article
- Single-cell transcriptomic profiling of the neonatal oviduct and uterus reveals new insights into upper Müllerian duct regionalization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Mapping uterine calcium dynamics during the ovulatory cycle in live mice.bioRxiv : the preprint server for biology · 2024Article
- Single-cell insights into epithelial morphogenesis in the neonatal mouse uterus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Sctensor detects many-to-many cell-cell interactions from single cell RNA-sequencing data.BMC bioinformatics · 2023Article
- Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signaling.PLoS biology · 2023Article
- Hox genes in development and beyond.Development (Cambridge, England) · 2023Article
- Biology-inspired data-driven quality control for scientific discovery in single-cell transcriptomics.Genome biology · 2022Article
- Single-Cell RNA-Sequencing Reveals Interactions between Endometrial Stromal Cells, Epithelial Cells, and Lymphocytes during Mouse Embryo Implantation.International journal of molecular sciences · 2022Article
- Morphogenesis of the female reproductive tract along antero-posterior and dorso-ventral axes is dependent on Amhr2+ mesenchyme in mice†.Biology of reproduction · 2022Article
- Contribution of the Wolffian duct mesenchyme to the formation of the female reproductive tract.PNAS nexus · 2022Article
- The Estrogen Receptor α Cistrome in Human Endometrium and Epithelial Organoids.Endocrinology · 2022Article
- Spatial transcriptomic profiles of mouse uterine microenvironments at pregnancy day 7.5†.Biology of reproduction · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The uterus is a remarkable organ that must guard against infections while maintaining the ability to support growth of a fetus without rejection. The Hoxa10 and Hoxa11 genes have previously been shown to play essential roles in uterus development and function. In this report we show that the Hoxa9,10,11, Hoxc9,10,11, Hoxd9,10,11 genes play a redundant role in the formation of uterine glands. In addition, we use single cell RNA-seq to create a high resolution gene expression atlas of the developing wild type mouse uterus. Cell types and subtypes are defined, for example dividing endothelial cells into arterial, venous, capillary, and lymphatic, while epithelial cells separate into luminal and glandular subtypes. Further, a surprising heterogeneity of stromal and myocyte cell types are identified. Transcription factor codes and ligand/receptor interactions are characterized. We also used single cell RNA-seq to globally define the altered gene expression patterns in all developing uterus cell types for two Hox mutants, with 8 or 9 mutant Hox genes. The mutants show a striking disruption of Wnt signaling as well as the Cxcl12/Cxcr4 ligand/receptor axis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.