ArticleScientific reports2019
DNA DSB Repair Dynamics following Irradiation with Laser-Driven Protons at Ultra-High Dose Rates.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- The current status of FLASH particle therapy: a systematic review.Physical and engineering sciences in medicine · 2023Pooled it
- Harnessing Particle Ions for FLASH Radiotherapy.Cells · 2026Review
- Microenvironmental remodeling in FLASH radiotherapy.Frontiers in cell and developmental biology · 2026Review
- The temporal response of a glioma cell population to irradiation: modelling the effect of dose and cell density.Royal Society open science · 2025Article
- FLASH-RT for pulmonary protection: a comprehensive review of mechanisms, technological advances, and clinical translation.Frontiers in oncology · 2025Review
- Emergence of FLASH‑radiotherapy across the last 50 years (Review).Oncology letters · 2024Review
- Current views on mechanisms of the FLASH effect in cancer radiotherapy.National science review · 2024Review
- Cumulative Dose from Recurrent CT Scans: Exploring the DNA Damage Response in Human Non-Transformed Cells.International journal of molecular sciences · 2024Article
- Recruitment Kinetics of XRCC1 and RNF8 Following MeV Proton and α-Particle Micro-Irradiation.Biology · 2023Article
- Transformative Technology for FLASH Radiation Therapy.Applied sciences (Basel, Switzerland) · 2023Article
- Time-of-flight spectroscopy for laser-driven proton beam monitoring.Scientific reports · 2022Article
- Development of a portable hypoxia chamber for ultra-high dose rate laser-driven proton radiobiology applications.Radiation oncology (London, England) · 2022Article
- A new platform for ultra-high dose rate radiobiological research using the BELLA PW laser proton beamline.Scientific reports · 2022Article
- Establishment ofFrontiers in public health · 2022Article
- Technical note: Providing proton fields down to the few-MeV level at clinical pencil beam scanning facilities for radiobiological experiments.Medical physics · 2022Article
- Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage.Scientific reports · 2021Article
- Association of Cancer Stem Cell Radio-Resistance Under Ultra-High Dose Rate FLASH Irradiation With Lysosome-Mediated Autophagy.Frontiers in cell and developmental biology · 2021Article
- Ultra-High Dose Rate FLASH Irradiation Induced Radio-Resistance of Normal Fibroblast Cells Can Be Enhanced by Hypoxia and Mitochondrial Dysfunction Resulting From Loss of Cytochrome C.Frontiers in cell and developmental biology · 2021Article
- PROTON BEAMS AND NOBEL LAUREATES.The Ulster medical journal · 2021Article
- Spectral and spatial shaping of laser-driven proton beams using a pulsed high-field magnet beamline.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protontherapy has emerged as more effective in the treatment of certain tumors than photon based therapies. However, significant capital and operational costs make protontherapy less accessible. This has stimulated interest in alternative proton delivery approaches, and in this context the use of laser-based technologies for the generation of ultra-high dose rate ion beams has been proposed as a prospective route. A better understanding of the radiobiological effects at ultra-high dose-rates is important for any future clinical adoption of this technology. In this study, we irradiated human skin fibroblasts-AG01522B cells with laser-accelerated protons at a dose rate of 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.