ArticleScientific reports2019
Functional divergence of thyrotropin beta-subunit paralogs gives new insights into salmon smoltification metamorphosis.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Photoperiodic history modulates the response of the saccus vasculosus transcriptome to seawater exposure in Atlantic salmon.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Article
- Emerging Perspectives on Gonadotropin Regulation in Vertebrates Revealed by the Discovery of FSH-RH in Teleosts.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- The fish pituitary directly responds to daylength and drives seasonality.Proceedings. Biological sciences · 2025Article
- Crosstalk between thyroid hormones and the central corticotropin-releasing factor system in Atlantic salmon.Journal of neuroendocrinology · 2025Article
- Co-profiling of single-cell gene expression and chromatin landscapes in stickleback pituitary.Scientific data · 2025Article
- Day length regulates gonadotrope proliferation and reproduction via an intra-pituitary pathway in the model vertebrate Oryzias latipes.Communications biology · 2024Article
- Review
- New Insights Into the Evolution of Corticotropin-Releasing Hormone Family With a Special Focus on Teleosts.Frontiers in endocrinology · 2022Article
- Unconventional Actions of Glycoprotein Hormone Subunits: A Comprehensive Review.Frontiers in endocrinology · 2021Review
- Editorial: Plasticity in the Vertebrate Pituitary, Including Regulatory Mechanisms.Frontiers in endocrinology · 2021Article
- Differential Regulation of the Expression of the Two Thyrotropin Beta Subunit Paralogs by Salmon Pituitary CellsFrontiers in endocrinology · 2020Article
- Effects of Melatonin on Anterior Pituitary Plasticity: A Comparison Between Mammals and Teleosts.Frontiers in endocrinology · 2020Review
- Article
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Authors and funding
13 authors.
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Abstract
Smoltification is a metamorphic event in salmon life history, which initiates downstream migration and pre-adapts juvenile salmon for seawater entry. While a number of reports concern thyroid hormones and smoltification, few and inconclusive studies have addressed the potential role of thyrotropin (TSH). TSH is composed of a α-subunit common to gonadotropins, and a β-subunit conferring hormone specificity. We report the presence and functional divergence of duplicated TSH β-subunit paralogs (tshβa and tshβb) in Atlantic salmon. Phylogeny and synteny analyses allowed us to infer that they originated from teleost-specific whole genome duplication. Expression profiles of both paralogs in the pituitary were measured by qPCR throughout smoltification in Atlantic salmon from the endangered Loire-Allier population raised in a conservation hatchery. This revealed a striking peak of tshβb expression in April, concomitant with downstream migration initiation, while tshβa expression remained relatively constant. In situ hybridization showed two distinct pituitary cell populations, tshβa cells in the anterior adenohypophysis, and tshβb cells near to the pituitary stalk, a location comparable to the pars tuberalis TSH cells involved in seasonal physiology and behaviour in birds and mammals. Functional divergence of tshβ paralogs in Atlantic salmon supports a specific role of tshβb in smoltification.
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