ArticleScientific reports2019
Assessing whether the association between rheumatoid arthritis and schizophrenia is bidirectional: A nationwide population-based cohort study.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- The genetic basis for the inverse relationship between rheumatoid arthritis and schizophrenia.Molecular genetics & genomic medicine · 2020Pooled it
- Pooled it
- Potential preventive role of low-dose methotrexate against incident recorded psychosis: a retrospective cohort study based on electronic health records.EClinicalMedicine · 2026Article
- Schizophrenia and Rheumatoid Arthritis Genetic Scenery: Potential Non-HLA Genes Involved in Both Diseases Relationship.The Yale journal of biology and medicine · 2024Article
- Multimorbidity and the Etiology of Schizophrenia.Current psychiatry reports · 2024Review
- Neuroimmune, clinical and treatment challenges in multiple sclerosis-related psychoses.World journal of psychiatry · 2023Review
- Herpes Zoster Risk in Patients with Rheumatoid Arthritis and Its Association with Medications Used.International journal of environmental research and public health · 2023Observational
- Immunologic profiling in schizophrenia and rheumatoid arthritis.Psychiatry research · 2022Article
- Neuroimmune Crosstalk in Rheumatoid Arthritis.International journal of molecular sciences · 2022Review
- Autoantibody profiles associated with clinical features in psychotic disorders.Translational psychiatry · 2021Article
- Assessment of Subclinical Psychotic Symptoms in Patients with Rheumatoid Arthritis and Spondyloarthritis.Journal of clinical medicine · 2021Article
- Dysbiosis, gut-blood barrier rupture and autoimmune response in rheumatoid arthritis and schizophrenia.Reumatologia · 2021Review
- Repurposing haloperidol for the treatment of rheumatoid arthritis: an integrative approach using data mining techniques.Therapeutic advances in musculoskeletal disease · 2021Article
- Immunoceptive inference: why are psychiatric disorders and immune responses intertwined?Biology & philosophy · 2021Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since many studies have shown a reduction in the incidence of rheumatoid arthritis (RA) in patients with schizophrenia (SCZ), little effort has been devoted to studying this link in the Asian population. Moreover, the relationship between these two disorders could be bidirectional, but the influence of RA on the SCZ incidence is unclear. The study aims to determine whether there is a bidirectional association between RA and SCZ in an Asian population. We analyzed a 10-year population- based longitudinal cohort using the National Health Insurance Research Database of Taiwan. In the first analysis, we included a total of 58,847 SCZ patients and 235,382 non-SCZ controls, and in the second analysis, a total of 30,487 RA patients and 121,833 non-RA controls, both matched by gender, age, and index date. Cox regression analyses were performed to examine the risk of RA incidence in the first analysis and the risk of SCZ incidence in the second analysis. The main finding of this study was the discovery of a lower incidence of RA in patients with SCZ (hazard ratio (HR): 0.48, 95% confidence interval (95% CI): 0.31-0.77) after adjustment for baseline demographics and comorbidities. Additionally, the presence of RA predicted a reduced incidence rate for SCZ, but the estimate was not statistically significant (HR: 0.77, 95% CI: 0.44-1.37). The study found a unidirectional association between RA and SCZ. However, RA has an age of onset later than RA, and the protective effect of RA on SCZ incidence would be biased due to the limited number of cases.
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